Abstract Modern therapeutic strategies for precancerous cervical intraepithelial neoplasia (CIN) focus on immune-modulatory and cancer vaccination. The local immune status in CIN could influence HPV infection persistence, progression carcinogenesis. We analysed the role of FOXP3+ regulatory T lymphocytes, CD4+ CD8+ lymphocytes I, II III patients with without infection. Sixty-two were enrolled s...

AIM To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. MATERIAL AND METHODS 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45RO-positive T lymphocytes in BM were detected using immunocytochemistry. All patients were thorou...

PURPOSE To elucidate the relation between infiltrating cytotoxic T lymphocytes and the expression of MUC1 and sialoglycans in malignant eyelid tumors. METHODS The distribution of MUC1, Maackia amurensis lectin-II (MAL-II)-recognized sialoglycan, and CD8-positive T lymphocytes was examined histochemically in 14 patients with malignant eyelid tumors: three squamous cell carcinomas, six sebaceou...

Most immunologists agree that CD8 T cells are important in controlling viruses, at least after the first week of infection – the time it takes for naive CD8 T cells to expand and differentiate into antiviral cytotoxic T lymphocytes (CTL). Nonetheless, CD8 T-cell measurements in HIV clinical studies show little relation to disease prognosis. There are two possible interpretations – either CD8 T ...

Proliferative renewal of memory CD8 T cells is essential for maintaining long-term immunity. In this study, we examined the contributions that various tissue microenvironments make toward the homeostatic proliferation of Ag-specific memory CD8 T cells. We found that dividing memory T cells were present in both lymphoid and nonlymphoid tissues. However, the bone marrow was the preferred site for...

Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach...

Human Mast Cells Modulate Proliferation and Cytokine Production by CD8+ T Lymphocytes F.L. Francina L. de Pater-Huijsen M.J. Mariëlle J. de Riemer R.M.R. Richard M.R. Reijneke M. Marjolein Pompen R. René Lutter H.M. Henk M. Jansen T.A. Theo A. Out Department of Pulmonology, Clinical and Laboratory Immunology Unit, Academic Medical Center and Laboratory for Experimental and Clinical Immunology (...

BACKGROUND Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer. OBJECTIVE To evaluate the effects of C. albicans structural and secreted proteins on intratumoral CD4/CD8 ratio as well as the survival rate in BALB/c t...

background: the aim of preliminary study was determined development process status of t-cell population lymphocytes in ukrainian children after 22 years from chernobyl accident for next feasibility study. material and method: 150 participants aged 6 to 16 years are included in three groups: group i (n=65), 30 to 60 km from center accident at zone 3th, group ii (n=65) 60 to 90 km from same locat...