Sickle cell disease (SCD) is associated with a complex vascular pathophysiology that includes activation of coagulation and inflammation. However, the crosstalk between these 2 systems in SCD has not been investigated. Here, we examined the role of tissue factor (TF) in the activation of coagulation and inflammation in 2 different mouse models of SCD (BERK and Townes). Leukocytes isolated from ...

By STANLEY L. LEE, LAWRENCE I. SCHWARTZ, AND SANFORD PARISER T HE L. E. CELL PHENOMENON is observed as a peculiar alteratioms hi the leukocytes of blood or boise marrow’ of patients with lupus em’ythematosus, induced by a constituent of the plasma or serum gamma globulin.t . 2 It does isot depend on amiy intritssic abmsormality of the leukocytes themselves atsd may be induced not only its leuko...

The coagulation process has been conceptualized as being primarily dependent on adequate levels of the coagulation proteins. This concept was based on the clear relationship between the bleeding tendency and factor levels in hemophilia. The field is now evolving toward conceptualizing coagulation as being actively regulated by the specialized cellular components of the process. Rather than conc...

The coagulation process has been conceptualized as being primarily dependent on adequate levels of the coagulation proteins. This concept was based on the clear relationship between the bleeding tendency and factor levels in hemophilia. The field is now evolving toward conceptualizing coagulation as being actively regulated by the specialized cellular components of the process. Rather than conc...

Activated protein C (APC) is a major control system of blood coagulation. APC prevents coagulation pathway by degrading Va and VIIIa plasma's coagulation factors. Protein C activation requires its binding to specific endothelial cell receptor (EPCR). APC binding to EPCR also activates a wide range of defense mechanisms (anti-inflammatory, antiapoptosis...). EPCR expression by cells can be detec...

The first model of coagulation was proposed in the 1960s. Although the cascade concept of coagulation represented a significant advance in understanding of coagulation system and served for many years as a useful model, more recent clinical and experimental observations demonstrate that the cascade/waterfall hypothesis does not fully and completely reflect the events of haemostasis in vivo. The...