Ovarian cancer is one of the major causes of death in women. Parabens are a class of chemicals widely used as preservatives in cosmetic and pharmaceutical products, they mimic estrogens, which are known to play a role in the development of different cancers in women. The Aim of this study was to investigate the proliferative effects of Methyl Paraben (MP) and Propyl Paraben (PP) on human ovaria...

The extracellular matrix (ECM) niche plays a critical role in determining cellular behavior during bone development including the differentiation and lineage allocation of skeletal progenitor cells to chondrocytes, osteoblasts, or marrow adipocytes. As major ECM component mineralized tissues, collagen has instructive as well structural roles is required for cell differentiation. Cells sense the...

Background: Type-I diabetes is an autoimmune inflammatory disease in which pancreatic ß-cells are selectively destroyed by infiltrating cells. TNF-related apoptosis-inducing ligand (TRAIL) is a type-II membrane protein of the TNF superfamily which is expressed in different tissues, including pancreas and lymphocytes. In humans, TRAIL interacts with four membrane receptors. TRAIL-R1 and TRAIL-R2...

Pattern Recognition Receptors (PRRs, [110]) (nomenclature as agreed by NC-IUPHAR sub-committee on Receptors, [20]) participate in the innate immune response to microbial agents, stimulation of which leads activation intracellular enzymes and regulation gene transcription. PRRs express multiple leucine-rich regions bind a range microbially-derived ligands, termed PAMPs or pathogen-associated mol...

osteopontin also known as bone sialoprotein (bsp). osteopontin role as a linking protein. it is an extracellular structural protein and therefore an organic component of bone. osteoprontin (opn) binds to several integrin receptors containing α4β1, α9β1, and α9β4 expressed by leukocytes. these receptors have been well-stable to function in cell adhesion, migration, and survival in these cells. i...

introduction: the neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. however, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. methods: here, we investigated the effects of different opioid agonists on 6-ohda-induced neurotoxicity in human neuroblastoma sh-s...

It has been shown that activated T-cells produce and release both IL-2 and IL- 2 receptors (lL-2R). The rate of IL-2 release is proportional to its cell surface expression and state of cell activation. To clarify the molecular basis of this immunological aberration, we analysed the amount of soluble IL-2R(SIL2-R) by an ELISA technique in 68 patients with Behcet's disease (BD), 28 patient co...