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conclusions this study provided conserved b-cell epitopes and peptides that can be useful for designing entry inhibitors and vaccines able to cover a global population, especially where genotype 5a is common. results differences in the probability of glycosylation in e1 and e2 regions were observed in this study. three conserved antigenic b-cell epitopes were predicted in the e2 regions and als...

1. Abstract 2. Introduction 3. Preparation of dendritic cells 3.1. Sources of dendritic cells 3.2. Dendritic cell mobilization strategies 3.3. Dendritic cell culture conditions 3.4. Methods of loading dendritic cells with tumor antigens 3.5. Dendritic cell maturation 3.6. The role of helper antigens 3.7. cryopreservation of dendritic cells 4. Administration of dendritic cell vaccines 4.1. Route...

Dendritic cell (DC)-based anticancer vaccines have yielded disappointing results in a multitude of clinical trials. New data suggest that the clinical efficacy of DC-based vaccines may be dependent on the paracrine production of interleukin-12 in the course of antigen presentation and the consequent development of therapeutic Type 1 CD8+ T-cell immunity.

Global population growth and rising health concerns have highlighted the importance of developing effective vaccination strategies, subunit vaccines hold great promise for meeting market demand. Compared to traditional whole-cell vaccines, contain only a part infectious microorganism induce an immune response against main pathogen.

Despite significant effort, the development of effective vaccines inducing strong and durable T-cell responses against intracellular pathogens and cancer cells has remained a challenge. The initiation of effector CD8(+) T-cell responses requires the presentation of peptides derived from internalized antigen on class I major histocompatibility complex molecules by dendritic cells (DCs) in a proc...

Objective(s): Brucellosis is a common infectious disease among animals and humans. While subunit vaccines could be used as an efficient strategy against pathogens, they usually seem to be less immunogenic than live or killed vaccines. However, the use of a suitable adjuvant accompanied by subunit vaccines can be a good alternative to enhance the immune response.Materials and Methods: To find a ...