Formation of root cementum is a crucial moment in the development of the periodontium. Cells that produce the cementum are named cementoblasts and they posses some unique characteristics, which differentiates them from osteoblasts. Bone morphogenetic proteins (BMPs) are crucial regulators of both bone and tooth formation. In animal studies BMPs have shown to induce periodontal regeneration, how...

The architectural heritage which has accumulated over thousands of years in the Mediterranean basin comprises a rich and complex record of the history of successive civilizations, embodying their long, intricate development. This heritage suffered considerably from the upheavals which characterised last century, and its conservation represents a major cultural commitment. While the Mediterranea...

Little is known about the molecular mechanisms that regulate the cementogenesis process, because specific cementum markers are not yet available. To investigate whether a cementoblastoma-conditioned medium-derived protein (CP) could be useful as a cementum biological marker, we studied its expression and distribution in human periodontal tissues, human periodontal ligament, alveolar bone, and c...

The major goal of periodontal therapy is periodontal regeneration including regeneration of alveolar bone, cementum and periodontal ligament fibres. Recapitulation of embryology shows the importance of Hertwig's epithelial root sheath (HERS), involved in cementogenesis and root formation. The remnants of these cells are found in normal periodontal ligament as the epithelial cell rests of Malass...

The roots of two incisors were treated by apicoectomy and a retrograde dentin-bonded composite filling. Periapical healing was observed a few months later by radiography. Later, due to root fracture and marginal bone resorption, the apical parts were removed including adjacent periapical bone. A histological and scanning electron microscopic examination of the tissue showed reformation of perio...

The emergence of Mineral Trioxide Aggregate (MTA) as endodontic repair filling material has generated a lot of interest due to its superior sealing ability and biocompatibility. Although MTA possesses superior sealing ability to traditional endodontic repair filling materials, such as calcium hydroxide, but it has poor handling characteristics. A novel endodontic repair filling materials with s...

Correspondence to: Francisco H. Nociti Jr. Av. Limeira 901 Caixa Postal: 052 CEP: 13414-903 Piracicaba S.P. Brazil Tel: ++ 55 19 34125298 Fax: ++ 55 19 3412 5218 E-mail: [email protected] Abstract This article reviews developmental and structural characteristics of cementum, a unique avascular mineralized tissue covering the root surface that forms the interface between root dentin and peri...