Dopamine has an effective role on gastric acid secretion (GAS). The role of peripheral and central dopamine D1/DA1 receptors on stimulated GAS are unknown. The objective of the present study was to use SKF38393 and SCH23390 on stimulated GAS. For all gastric sampling, animals (Sprague Dawley rats) were anesthetized and a polyethylene tube was introduced into the stomach through esophagus and a ...

The human histamine H 4 receptor (H 4 R), the most recently discovered histamine receptor, is predominantly expressed on inflammatory cells and lymphoid tissues and characterized as the immune system histamine receptor with a pro-inflammatory role. The occurrence of H 4 R on human and rodent neurons has also been recently reported, but, conversely to the well-characterized immunological role of...

WOODS, JAMES R., JR., C. R. BRINKMAN, III, A. DANDAVINO, K. MURAYAMA, AND N. S. ASSALI. Action of histamine and H, and H, blockers on the cardiopulmonary circulation. Am. J. Physiol. 232(l): H73-H78, 1977 or Am. J. Physiol.: Heart Circ. Physiol. l(1): H73-H78, 1977. -Systemic and pulmonary hemodynamic responses to histamine were investigated in chronically instrumented unanesthetized nonpregnan...

e have known about histamine receptors in the heart for any years (1). The human H1and H2-histamine recepors were cloned and characterized in the early 1990s (2,3), ollowed closely by the human H3and H4-histamine eceptors several years later (4,5). Histamine is a natural ody constituent that is found throughout the body, espeially the central nervous system, mast cells, gastric mucosa arietal c...

T he existence of histamine receptors and histamine in the heart has been known since at least the 1940s (1) and cloning of human histamine receptors began around the 1990s (2). Nevertheless, developments relating to histamine have not been highlighted. Also, its role in cardiovascular physiology, such as in the renin–angiotensin or the sympathetic nervous system where it is central to understa...

Central histaminergic neurons have been implicated in the control of oxytocin (OT) secretion in various physiological conditions, including parturition and lactation. The present studies investigated whether histamine also influences the central intranuclear release of OT, which is known to be important in the activation of OT neurons, and the possible interaction of histamine with norepinephri...

Dopamine has an effective role on gastric acid secretion (GAS). The role of peripheral and central dopamine D1/DA1 receptors on stimulated GAS are unknown. The objective of the present study was to use SKF38393 and SCH23390 on stimulated GAS. For all gastric sampling, animals (Sprague Dawley rats) were anesthetized and a polyethylene tube was introduced into the stomach through esophagus and a ...

Systemic and pulmonary hemodynamic responses to histamine were investigated inchronically instrumented unanesthetized nonpregnant ewes. Histamine was administered intravenously and into the pulmonary artery. The effects of the same doses of histamine were assessed following H1 and H2 receptor blockade. The effects ocular changes were also monitored. Results indicate that intravenous histamine p...

Histamine and histamine receptors in the central nervous system actively participate in the modulation of motor control. In clinic, histamine-related agents have traditionally been used to treat vestibular disorders. Immunohistochemical studies have revealed a distribution of histaminergic afferents in the brainstem vestibular nuclei, including the lateral vestibular nucleus (LVN), which is cri...

Histamine and its receptors were first described as part of immune and gastrointestinal systems, but their presence in the central nervous system and importance in behavior are gaining more attention. The histaminergic system modulates different processes including wakefulness, feeding, and learning and memory consolidation. Histamine receptors (H1R, H2R, H3R, and H4R) belong to the rhodopsin-l...