Continuous erythropoietin receptor activator (CERA) seems to maintain a stable hemoglobin (Hb) level because its half-life is longer than darbepoetin α (DA). Twenty chronic kidney disease (CKD) patients at the pre-dialysis stage who had been administered DA for over 24 weeks were randomly assigned to receive subcutaneous CERA or DA once every four weeks during 48 weeks. In both groups, the rate...

Chronic kidney disease (CKD) is known to increase myocardial infarct size after ischemia/reperfusion. However, a strategy to prevent the CKD-induced myocardial susceptibility to ischemia/reperfusion injury has not been developed. Here, we examined whether epoetin β pegol, a continuous erythropoietin receptor activator (CERA), normalizes myocardial susceptibility to ischemia/reperfusion injury b...

The increased deposition of iron in the kidneys that occurs with glomerulopathy hinders the functional and structural recovery of the tubules and promotes progression of chronic kidney disease (CKD). Here, we evaluated whether epoetin beta pegol (continuous erythropoietin receptor activator: CERA), which has a long half-life in blood and strongly suppresses hepcidin-25, exerts renoprotection in...

The aim of this study was to evaluate the marginal adaptation of Turkom-Cera all-ceramic crowns compared to In-Ceram and Procera AllCeram systems. The influence of finish line design (chamfer or shoulder) on the marginal adaptation of Turkom-Cera all-ceramic crowns was also investigated. Thirty human premolars were prepared with chamfer margins and assigned to either the Turkom-Cera, In-Ceram, ...

BACKGROUND To evaluate the accuracy and reliability of fundus retinal photos graded by local graders in Bangladesh with those graded by an expert at the Centre for Eye Research Australia (CERA) in the context of mass scale diabetic retinopathy (DR) screening in Bangladesh. METHODS A population-based cross-sectional study of 3,104 adults identified 213 (7.2%) eligible patients with diabetes of...

Caching has been used for decades as an effective performance enhancing technique in computer systems, among others. However, the traditional cache replacement algorithms are not easily applicable to WWW applications. Moreover, the frequently used hit-ratio and byte-hit ratio are not appropriate measures in WWW applications, because non-uniformity of the object sizes and non-uniformity cost of ...

BACKGROUND & OBJECTIVES Chronic kidney disease (CKD) patients on dialysis regularly receive erythropoiesis stimulating agent (ESA) for treating renal anaemia during their dialysis unlike those who are not on dialysis. In such patients, the longer acting ESA can be helpful in reducing their frequent visits to the health care facilities and improving their compliance. This study was aimed to exam...

Red cell production in chronic kidney disease is usually too low to maintain a normal haemoglobin, and thus anaemia develops in a large proportion of patients. The ability to stimulate erythropoiesis in the bone marrow by the use of therapeutic agents has only been possible in the last 20 years, initially with recombinant human erythropoietin (epoetin), and later darbepoetin alfa. Many new agen...

AIM The objective of this study is to investigate the effect of different luting agents on the fracture strength of Turkom-Cera all-ceramic copings. METHODS AND MATERIALS Standardized metal dies were duplicated from a prepared maxillary first premolar tooth using non-precious metal alloy (Wiron 99). Thirty Turkom-Cera copings of 0.6 mm thickness were then fabricated. Three types of luting age...

BACKGROUND Continuous erythropoietin receptor activator (CERA; methoxy polyethylene glycol-epoetin beta) is a new erythropoiesis-stimulating agent with a prolonged half-life. The objective of this study was to select a starting dose of CERA for the treatment of anemia in non-small-cell lung cancer (NSCLC) patients. PATIENTS AND METHODS The study was an open-label randomized phase II trial con...