Cerebral aneurysm rupture and subarachnoid hemorrhage (SAH) inflict disability and death on thousands of individuals each year. In addition to vasospasm in large diameter arteries, enhanced constriction of resistance arteries within the cerebral vasculature may contribute to decreased cerebral blood flow and the development of delayed neurological deficits after SAH. In this study, we provide n...

In helically-cut strips of cerebral arteries isolated from dogs, serotonin, tryptamine, 5-hydroxytryptophan and tryptophan caused a dose-related contraction. The potency was in the order of serotonin greater than tryptamine much greater than 5-hydroxytryptophan = tryptophan. In femoral arterial strips, only serotonin and tryptamine produced contractions. In cerebral arteries, the dose-response ...

Cerebral aneurysm rupture and subarachnoid hemorrhage (SAH) inflict disability and death on thousands of individuals each year. In addition to vasospasm in large diameter arteries, enhanced constriction of resistance arteries within the cerebral vasculature may contribute to decreased cerebral blood flow and the development of delayed neurological deficits after SAH. In this study, we provide n...

are major determinants of local microvascular pressure. Recent studies have shown that resistance of large arteries and cerebral microvascular pressure are affected by several physiological stimuli, including changes in systemic blood pressure, increases in cerebral metabolism, activity of sympathetic nerves, and humoral stimuli such as circulating vasopressin and angiotensin. Stimuli such as s...

Abstract We report a case of 4-year-old boy who presented with moyamoya disease associated midaortic syndrome. He had been treated for severe persistent hypertension until he suffered multiple episodes seizure and cerebral ischemic attack. Cerebral angiography showed bilateral terminal internal carotid artery stenosis. Angiographic survey stenosis abdominal aorta proximal renal arteries. This i...

BACKGROUND AND PURPOSE The relation between serum total cholesterol levels and stroke is controversial. The Akita Pathology Study provides data on the association of serum total cholesterol, different types of stroke, and distribution of stenosis in cerebral arteries. METHODS The data are based on 750 autopsied men aged 30 years and older who were admitted to a local hospital in northeast Jap...

· Posterior Circulation Two vertebral arteries originate from the first part of the subclavian arteries. These join intra-cranially to form the basilar artery and supply the posterior cerebral circulation. This is the main blood supply to the brain stem, cerebellum and posterior cerebrum. · Anterior Circulation Both internal carotid arteries arise from the carotid bifurcation in the neck. Intra...