Introduction: Nitric oxide seems to play a dual role in ischemia/reperfusion injury. Few studies have investigated whether it exacerbates or improves brain edema. In the present study, we inhibited the activity of nitric oxide synthase by L-NAME and evaluated the cerebral infarct volume, tissue swelling and brain edema, alongside the measurement of blood flow of the ischemic region. Methods...

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...

Background: Beta-thalassemia intermedia (BTI) is a type of hemoglobinopathy with an increased risk of cerebrovascular accidents, and transcranial cerebral Doppler ultrasonography (TCD) through determining the mean cerebral blood flow velocity (CBFV) can serve to predict the risk of a developing stroke. This study aims to compare patients with beta-thalassemia intermedia and healthy individuals ...

background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...

background: to determine whether islamic fasting would change cerebral blood flow during ramadan. methods: the study group comprised 20 subjects (16 males and 4 females) on a regimen of 1 month food and water intake restriction, according to islamic fasting ritual. subjects were evaluated for cerebral bolo flow through a middle cerebral artery (mca) by means of transcranial doppler (tcd), the d...