BACKGROUND AND OBJECTIVES This study examined the risks, predictors, and mortality implications of cerebrovascular disease events after kidney transplantation in a national cohort. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This analysis used United States Renal Data System registry data to study retrospectively Medicare-insured kidney transplant candidates (n = 51,504), recipients (n = 29...

Cerebral Circulation Studies Using Inhaled 133-Xenon and the Gamma Camera • Inhaled 133-xenon was utilized in conjunction with the Anger gamma scintillation camera to evaluate cerebral circulation in 20 asymptomatic control subjects and in 41 patients with clinical cerebrovascular disease. Sequental cerebral scintiphotos thus obtained revealed focal areas of decreased activity in 2 of 19 contro...

This review focuses on two gaseous cellular messenger molecules, CO and H2S, that are involved in cerebrovascular flow regulation. CO is a dilatory mediator in active hyperemia, autoregulation, hypoxic dilation, and counteracting vasoconstriction. It is produced from heme by a constitutively expressed enzyme [heme oxygenase (HO)-2] expressed highly in the brain and by an inducible enzyme (HO-1)...

In the present study, the dynamics of the cerebral blood flow (CBF) and ventilatory response to hypercapnia was investigated in a group of patients with cerebrovascular disease and compared to responses measured in a group of normal volunteers. There was a significant correlation between the rapidity of the transient CBF and ventilatory responses and the severity of the cerebrovascular disease....

A technique for analysis of dynamic radionuclide studies of the cerebral circulation is described. This technique permits objective classification of observed radionuclide distribution patterns. Variation in the time-to-peak activity, and in the maximum attained activity as determined by region-of-interest analysis of cerebral hemispheric activity, was defined for a normal population. Applicati...

The influence of sympathetic nervous activity on cerebral circulation and cerebrovascular CO2 reactivity was investigated by an ƒ¿-adrenergic blockade with phenoxybenzamine (PBZ). Cerebral oxygen and carbon dioxide tension (BrPO2, BrPCO2) and arterial blood pressure were continuously recorded before, during and after intracarotid infusion of 5 mg/kg of PBZ. The effects of 5% CO2 inhalation were...

BACKGROUND AND PURPOSE Endothelial progenitor cells (EPCs) are associated with endothelial repair after ischemia in cardiac or peripheral circulation. There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease. SUMMARY OF REPORT EPC counts differed significantly (P<0.001) between stroke patients (acute stroke: median...