Cervical cancer is the third most common cancer in women worldwide. The role of human papilloma virus (HPV) in the genesis of cervical carcinoma is well documented. The HPV 16 and 18 are found to be most commonly associated with invasive cervical carcinoma. The advent of cervical carcinoma vaccine has advanced the hopes that eradication of cervical carcinoma might be possible in future. The sce...

Background: This research was accomplished to evaluate the IHC expression of p16 (ink4a) and CK17 in low grade cervical intraepithelial lesions (LSIL), high grade cervical intraepithelial lesions (HSIL) and invasive cervical carcinomas and to assess their correlation to HPV (16E6+18E6). Methods: The study...

THE ANTITUMOR ACTIVITY OF ROSCOVITINE WAS TESTED IN FOUR CERVICAL CARCINOMA CELLS: C33A, HCE-1, HeLa, and SiHa. The effects of roscovitine on ATP Lite assay, cell cycle, and apoptosis were assessed. The Sub-G1 DNA content occurred great increasing, and this indicates that apoptosis was induced quickly in HeLa cells, but slowly in the other cells. The morphological observation results showed tha...

Introduction: Although cervical carcinoma is common, cutaneous metastasis from this tumor is rare. The reported incidence rates of skin metastasis from cervical cancer range from 0.1% to 1.3%. The major histological subtype of cervical carcinoma is squamous cell carcinoma (SCC), accounting for 75% of cases. The remainder are classified as adenocarcinoma, adenosquamous cell carcinoma, or are of ...

Epidermal growth factor receptor (EGFR) is overexpressed in a variety of malignancies, including breast, lung, gastric, and cervical carcinoma. Its overexpression has been associated with disease progression or poor prognosis in patients with cervical carcinoma. In the present study, the levels of EGFR were determined in serum from 38 patients with cervical carcinoma [invasive or recurrent carc...

This study aimed to investigate the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma and to explore the biological processes and signal pathways related to cervical carcinoma. Cervical carcinoma tissue specimens from 200 patients and normal tissue specimens adjacent to lesions from 30 cases were collected in this study. Ki67 and FasL proteins in these spec...

Neoplasm in the vagina which occurs following treatment of cervical carcinoma could represent a separate primary neoplasm, a “field” response to a common carcinogen, or be due to neoplastic transformation of tissue from previous radiation treatment. Fifty patients with a second neoplasm in the vagina were identified: 17 following total hysterectomy for carcinoma in situ of cervix; 4 following r...

Fibulin-4, a member of the fibulin family of extracellular glycoproteins, is implicated in the progression of a number of types of cancer. However, the function of fibulin-4 in cervical cancer progression remains unexplored. Fibulin-4 mRNA and protein expression levels in normal cervical tissue, cervical intraepithelial neoplasia (CIN), cervical carcinoma, highly invasive subclones and low-inva...

A case of collision carcinoma (squamous cell carcinoma and Barrett's adenocarcinoma) in the residual cervical esophagus of a 68-year-old woman at 27 years after subtotal esophagectomy for thoracic esophageal carcinoma is reported. The patient initially noticed cervical dysphagia in 2002, but did not seek treatment. In April 2004, the patient was referred to our department by a local physician w...

papillary microcarcinoma of thyroid (pmc) as a variant of papillary carcinoma less than 1 cm in size is a new clinicopathological entity, with high incidence and good prognosis. there are many differences between pmc and clinically apparent papillary thyroid carcinoma. also, there are some pmc case reports with unusual metastasis and aggressive courses. prognostic factors are age, size and morp...