tumor size seems to be a determinant in the prognosis of early cervical cancer. patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.' the purpose of this study was to compare the efficacy of preoperative combined chemoradiation and neoadjuvant chemotherapy (narc) programs followed by radical hysterectomy in stage ib - lib bulky cervical cancer. from september ...

Background: Tumor metastasis, as one of the most important prognostic factors in solid tumors, affects survival remarkably. Cervical lymphadenopathy (LAP) reflects an advanced-stage disease and changes tumor-node-metastasis (TNM) staging tumor, resulting a multidisciplinary approach to management cancer. Objectives: This study aimed assess importance neck sonography monitoring primary tumors. M...

Interleukin (IL) 17 is a proinflammatory cytokine secreted mainly by activated human memory CD4 T cells that induces IL-6, IL-8, and nitric oxide. Because IL-6 and IL-8 have been implicated in the pathogenesis of cervical cancer, we investigated the action of IL-17 on human cervical tumor cell lines in vitro and in vivo. We showed that in vitro, IL-17 increases IL-6 and IL-8 secretion by cervic...

Background & Objectives: Tumor diathesis (TD) is defined as granular proteinaceous precipitates on slide surface of cytologic smears. It is found in the background of smears of invasive carcinoma but not in all cases. The aim of present study was to determine the prevalence of TD in cervicovaginal smears from patients with uterine cervix carcinoma. Methods: Cytological smears and histological ...

To report a rare case of axis brown tumor and to review literature of cervical spine brown tumor. Brown tumor is a rare bone lesion, incidence less than 5% in primary hyperparathyroidism. It is more common in secondary hyperparathyroidism with up to 13% of cases. Brown tumor reactive lesion forms as a result of disturbed bone remodeling due to long standing increase in parathyroid hormones. Cer...

BACKGROUND T cell immunoglobulin mucin-3 (Tim-3) has been identified as a negative regulator of anti-tumor immunity. Recent studies highlight the important role of Tim-3 in the CD8(+) T cell exhaustion that takes place in both human and animal cancer models. However, the nature of Tim-3 expression in the tumor cell and the mechanism by which it inhibits anti-tumor immunity are unclear. This pre...

Sphingosine kinase 1 (SPHK1), an oncogenic kinase, has previously been found to be upregulated in various types of human malignancy and to play a crucial role in tumor development and progression. Although SPHK1 has gained increasing prominence as an important enzyme in cancer biology, its potential as a predictive biomarker and a therapeutic target in cervical cancer remains unknown. SPHK1 exp...

Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. It has been very rarely reported as lateral cervical mass in English literature. Myeloid sarcoma has also been reported with marked eosinophilia. Here we present a 17 year old boy with lateral cervical mass and persistent eosinophilia. The mass was isointense in MRI and homogenously enhanced after contrast injection which...

Aim: Osteoprotegerin (OPG) is associated with breast cancer in women; however, its role in cervical cancer remains unknown. This study was to investigate the association between tumor OPG expression and the prognosis in cervical cancer patients. Methods: A total of 218 patients with primary cervical cancer were enrolled in this study. All patients underwent surgical treatment as primary treatme...