CIS of the human cervix uteri is widely accepted as a preinvasive lesion that often progresses to invasive squamous carcinoma. Similarly, CIS is believed to arise by progression from cervical dysplasia, the earliest detectable neoplastic change in cervical epithelium (16). However, there is disagree ment as to how often there is progression from dysplasia to CIS and from CIS to invasive carcino...

Chromosome counts and karyotypes were prepared from samples of dysplasia and carcinoma in situ of the uterine cervix in 14 patients with the use of tissue culture technics. The material for initial culture was identified as neoplastic epithelium in vivo by colpomicroscopy. Then a biopsy was obtained from within this area; one half was fixed for histologie examination, and in the remaining half,...

Cytomegalovirus and Chlamydia trachomatis are prevalent sexually transmissible pathogens. They produce persistent infections of the cervix and have been associated with cervical neoplasia. Cytomegalovirus has also been shown to induce transformation of cells in culture. Because of the high prevalence of genital infections with these pathogens and evi dence that they may have oncogenic effects o...

The majority of squamous cell carcinomas of cervix are preceded by visible changes in the cervix, most often detected by cervical smear. As cervical cancer is preceded by long precancerous stages, identification of the high-risk population through detection of DNA ploidy may be of importance in effective management of this disease. Here we attempted to correlate aneuploid DNA patterns and their...

CIS of the human cervix uteri is widely accepted as a preinvasive lesion that often progresses to invasive squamous carcinoma. Similarly, CIS is believed to arise by progression from cervical dysplasia, the earliest detectable neoplastic change in cervical epithelium (16). However, there is disagree ment as to how often there is progression from dysplasia to CIS and from CIS to invasive carcino...

BACKGROUND Cancer of the cervix is the commonest malignancy of the genital tract in Nigeria. In an atmosphere of opportunistic screening due to lack of a national screening programme, studies are needed to determine patients at risk of premalignant lesions of the cervix. GOAL To determine cervical smear pattern in patients with chronic pelvic inflammatory disease and investigate the potential...

Carcinoma of cervix is the third most common cancer in women worldwide & most common female cancer in many developing countries like India. The present study was done with an objective to correlate the finding in women with unhealthy cervix by cytology and cervical biopsy and to assess the utility of these in detecting the premalignant and malignant lesions of the cervix. The sensitivity, speci...

Aim: To evaluate the premalignant and malignant lesions of the uterine cervix on light microscopy for apoptosis. To calculate and correlate the apoptotic index (AI), mitotic index (MI) and turnover index of the lesions. Materials and methods: A 2-year retrospective (November 2007 to October 2009) and 1-year prospective study (November 2009 to October 2010). A total of 95 cases of premalignant a...

Cytomegalovirus and Chlamydia trachomatis are prevalent sexually transmissible pathogens. They produce persistent infections of the cervix and have been associated with cervical neoplasia. Cytomegalovirus has also been shown to induce transformation of cells in culture. Because of the high prevalence of genital infections with these pathogens and evidence that they may have oncogenic effects on...

INTRODUCTION High-risk human papilloma viruses play a main role in the development of cervical dysplasias and carcinomas. p16INK4a can be considered as a surrogate marker of active high-risk human papillomaviruses infection in dysplastic and neoplastic cells of the cervix. This study was aimed at determining the presence and level of pl6INK4a expression in inflammatory, preneoplastic and neopla...