As understanding of corporate responsibility grows so does the recognition of the complexity and scale of the challenge it represents for companies. It is no longer enough to have a Corporate Responsibility (CR) team – CR is expected to be integrated across an organisation’s entire business. What are the skills, competencies and knowledge required if CR is to be integrated across organisations,...

Chromium (Cr) causes delayed-type hypersensitivity reactions possibly mediated by accumulating T cells into allergic inflamed skin, which are called irritants or allergic contact dermatitis. However, accumulating T cells during development of metal allergy are poorly characterized because a suitable animal model is not available. This study aimed to elucidate the skewing of T-cell receptor (TCR...

Cr(VI) causes severe kidney damage. The patient's renal function could gradually recover by spontaneous kidney regeneration. The molecular effect of Cr(VI) on recovery of kidney cells, however, has not been clearly elucidated. Here we show that Cr(VI) induces expression of mesenchymal and stem cell markers, cell markers, such as paxillin, vimentin, α-SMA, nanog, and CD133 of HK-2 cells. Moreove...

BACKGROUND Osteochondral defects continue to be a clinical treatment challenge, and when left untreated, may cause pain and functional impairment. Pyrolytic carbon is a unique isotropic biomaterial used in heart valve and small joint replacements due to its excellent wear properties and biocompatibility with bone and articular cartilage. Therefore, a proposed solution is to utilize a focal pyro...

BACKGROUND A growing body of research suggests that elevated circulating levels of glucose and insulin accelerate risk factors for a wide range of disorders. Low-risk interventions that could suppress glucose without raising insulin levels could offer significant long-term health benefits. METHODS To address this issue, we conducted two sequential studies, the first with two phases. In the fi...

Acute lymphoblastic leukemia (ALL) treatment regimes are amongst the longest, most intensive and complex used in hematooncology. Despite this, while treatment of pediatric ALL is a success story, we are far from being able to ensure a durable response in adult ALL. This is not due to failure of induction therapy as a complete remission (CR) is achieved in over 90% of patients. However the chall...

The rising number and capacity requirements of wireless systems bring increasing demand for RF spectrum. Cognitive radio (CR) system is an emerging concept to increase the spectrum efficiency. CR system aims to enable opportunistic usage of the RF bands that are not occupied by their primary licensed users in spectrum overlay approach. In this approach, the major challenge in realizing the full...

PURPOSE Complete remission (CR) is uncommon during treatment for metastatic renal cell carcinoma (mRCC) with tyrosine kinase inhibitors (TKIs), but it may occur in some patients. It remains a matter of debate whether therapy should be continued after CR. METHODS A multicenter, retrospective analysis of a series of patients with mRCC who obtained CR during treatment with TKIs (sunitinib or sor...

The rising number and capacity requirements of wireless systems bring increasing demand for RF spectrum. Cognitive radio (CR) system is an emerging concept to increase the spectrum efficiency. CR system aims to enable opportunistic usage of the RF bands that are not occupied by their primary licensed users in spectrum overlay approach. In this approach, the major challenge in realizing the full...

Abstract Background Interest in the use of natural feed additives as an alternative to antimicrobials poultry industry has increased recent years because risk bacterial resistance. One most studied groups are polyphenolic compounds, given their advantages over other types and easy potentiation effects when complexes formed with metal ions. Therefore, objective present study was evaluate impact ...