نتایج جستجو برای: chamber avoidance test
تعداد نتایج: 883373 فیلتر نتایج به سال:
Background: The toxic effect of sodium arsenate on nervous system has been shown; but the protective effects of several compounds against sodium arsenate are not clear. This study aimed to investigate the protective effects of nicotine and bucladesine, two positive modulators of neuronal function, on sodium arsenate toxicity against avoidance memory impairment. Methods: Male mice (N=154) were ...
Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer’s disease (AD). This research aimed to investigate ...
MALIN, D. H. Synthetic scotophobin: analysis of behavioral effects on mice. PHARMAC. BIoCHEM. BEHAV. 2(2) 147-153, 1974. Scotophobin is a peptide previously identified [ 141 as the behaviorally active factor in brain extract of rats trained in passive dark avoidance. Mice injected intraperitoneally with a synthetic version of scotophobin or placebo were tested without reinforcement in a box wit...
abstract introduction: diabetes mellitus accompanies with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. considering the beneficial antidiabetic potential of apium graveolens (ag ), this research study was conducted to evaluate the effect of chronic i.p. administration of ag on learning and memory in diabetic rats using passive avoidance ...
Introduction: Nitric oxide is an important messenger in hippocampal region which is affected in learning and memory processes and hippocampal responses to stress. In this study, we investigated the effect of L-NAME on passive avoidance memory in adult male rats exposed to restraint-stress. Methods: For this purpose, male Wistar rats were bilaterally implanted with cannulas aimed at the CA1 r...
Introduction: Evidence indicates that morphine impairs memory process. Ghrelin hormone has been linked to learning and memory processes and modulates reward properties of addictive drugs. In this study we examined the role of middle septal ghrelin receptors in the effects of morphine on memory consolidation in passive avoidance learning. Materials & Methods: In this experimental study, 91 ma...
The search for alternative methods to euthanize piglets is critical to address public concern that current methods are not optimal. Scientific evidence supports that blunt force trauma is humane when performed correctly, but most people find it visually difficult to accept. The use of CO2 is often recommended; at the same time, it is criticized as being aversive to pigs. This research sought to...
One of the challenges in pharmacological screening is to maximize the throughput of tests in order to evaluate the potential efficacy of a large number of compounds in a minimal amount of time. The inhibitory avoidance test, also called passive avoidance, has long been used as a screening test to evaluate drug effects on the memory in rodents [1,2]. The test is based on the natural photophobia ...
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