this study seeks to examine how a company can select the best intermediary for its marketing channels with minimum of criteria and time. a theoretical framework is proposed based on the most important tasks of intermediary and the criteria to measure them. there are four basic tasks and thirty criteria in three independent levels. subsequently, an exploratory case study in iranian food industry...

Synonymous mutations are usually referred to as "silent", but increasing evidence shows that they are not neutral in a wide range of organisms. We looked into the relationship between synonymous codon usage bias and residue importance of voltage-gated ion channel proteins in mice, rats, and humans. We tested whether translationally optimal codons are associated with transmembrane or channel-for...

Escherichia coli α-hemolysin (HlyA) is a pore-forming protein of 110 kDa belonging to the family of RTX toxins. A hydrophobic region between the amino acid residues 238 and 410 in the N-terminal half of HlyA has previously been suggested to form hydrophobic and/or amphipathic α-helices and has been shown to be important for hemolytic activity and pore formation in biological and artificial memb...

As part of a comparative study of the cell wall of corynebacteria, a channel-forming protein was characterized in Corynebacterium amycolatum, a species devoid of corynemycolic acids. Corynebacterium amycolatum cells were disrupted and the cell envelope subjected to two different separation procedures, differential centrifugation to separate the different fractions of the cell envelope, and sucr...