نتایج جستجو برای: chemoimmunotherapy
تعداد نتایج: 698 فیلتر نتایج به سال:
Adult C57BL/6 mice given syngeneic Friend lymphoma cells (FBL-3) usually died on Day 12 to 15. Treatment on Day 5 with cyclophosphamide (CY), 180 mg/kg, and lymphoid cells from C57BL/6 mice immunized with FBL-3 cured most mice, whereas cells alone had no effect and CY alone or with nonimmune cells only doubled the median survival time. As an adjunct to CY, at least 3 X IO6 spleen cells or perip...
Augmentation of specific chemoimmunotherapy by daily, intrasplenic injection of interleukin-2 (IL-2) was assessed in a methylcholanthrene (MCA)-induced fibrosarcoma model in C3H/HeJ mice. Daily access to the spleen was achieved by relocating the organ into the subcutis while leaving its blood supply intact. Following intrasplenic injection of 80 units of human IL-2 into MCA-F tumor-bearing mice...
BACKGROUND On the basis of promising results that were reported in several phase 2 trials, we investigated whether the addition of the monoclonal antibody rituximab to first-line chemotherapy with fludarabine and cyclophosphamide would improve the outcome of patients with chronic lymphocytic leukaemia. METHODS Treatment-naive, physically fit patients (aged 30-81 years) with CD20-positive chro...
The publication of two large randomized studies – the ENGOT-EN-6-NSGO/GOG-3031/RUBY trial and NRG-GY018 which investigated combining chemotherapy with immunotherapy to treat patients primary advanced or recurrent endometrial cancer (EC) has transformed clinical study landscape in terms first-line therapy for affected set a new standard therapy. In trial, addition dostarlimab carboplatin paclita...
We investigated the effects of anticancer agents on peripheral blood mononuclear cells for the purpose of providing data to support new translational chemoimmunotherapy regimens. Peripheral-blood mononuclear cells were treated with one of four anticancer agents (5-fluorouracil, irinotecan, cisplatin, and gemcitabine) for 2 h, after which cell viability was determined. For assessment of effects ...
BACKGROUND/AIM Chemoimmunotherapy has been used to treat intrahepatic cholangiocarcinoma (ICC). However, little is known about the phenomena underlying the immunomodulation of ICC cells elicited by chemoimmunotherapy. MATERIALS AND METHODS Primary ICC cells from a patient with ICC who received gemcitabine followed by 5-fluorouracil (5-FU), both combined with dendritic cells pulsed with Wilms'...
The introduction of targeted therapy against CD20(+) with the monoclonal antibody rituximab has dramatically improved the survival of B-cell non-Hodgkin lymphoma including chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma. Unfortunately, CLL remains incurable with chemoimmunotherapy, with many patients having refractory or relapsing disease after rituximab-containing therapy. Obinut...
BACKGROUND Radiotherapy is a commonly used treatment for limited-stage ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) but showed a substantial relapse risk if the disease involves beyond-conjunctiva or bilateral conjunctivae. Systemic chemoimmunotherapy may be an alternative frontline therapy for the limited disease with those adverse prognostic factors. PATIENTS AND METHODS...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید