Study on bioconversion of ω-fatty acids extracted from giant snakehead (Channa micropeltes) fish oil was carried out using guinea pig lung homogenate. The fish oil, after hydrolysis to their fatty acids, was incubated aerobically at 37oC in phosphate buffer solution with the addition of guinea pig lung homogenate. After incubation and chemoreduction, it was found that ca. 76% arachidonic acid h...

BACKGROUND Primary chemotherapy is a new treatment approach in retinoblastoma, aiming to avoid radiogenic adverse effects, such as second tumor-associated mortality, as observed following external beam irradiation. OBJECTIVE To describe the clinical and histopathologic regression pattern after primary chemotherapy in retinoblastoma. METHODS Five patients with sporadic bilateral retinoblasto...

PURPOSE To determine ocular survival and factors affecting globe survival in patients diagnosed with retinoblastoma at King Hussein Cancer Center (KHCC). METHODS A retrospective review of medical records of 71 Jordanian patients (45 males and 26 females) diagnosed with retinoblastoma (114 eyes) between June 2003 and May 2013 was conducted. Patient sociodemographic and relevant characteristics...

purpose : to evaluate the effectiveness of chemoreduction (crd) for globe saving in patients with intraocular retinoblastoma methods : in this interventional case series all patients with intraocular retinoblastoma were included and classified according to the international classification of retinoblastoma (icrb) from group a to e. six cycles of intravenous vincristine, etoposide and carboplati...

Retinoblastoma is the most common intraocular tumor in childhood. In majority of early stage retinoblastoma, the eyeballs as well as vision can be preserved with chemotherapy and local intraocular therapy with laser or photocoagulation. However, more than half the patients in India and other developing nations present in advanced stage of the disease. This article reviews the genetics, clinical...

OBJECTIVE To evaluate the results of thermotherapy for retinoblastoma. DESIGN Prospective, nonrandomized analysis of the treatment method. PARTICIPANTS A total of 188 retinoblastomas in 80 eyes of 58 patients who were treated with thermotherapy. MAIN OUTCOME MEASURES Tumor response and ocular adverse effects. RESULTS Of 188 retinoblastomas treated with thermotherapy, mean tumor base was...

Intraocular (IO) retinoblastoma (RB) has traditionally been treated with enucleation (ENU) or external beam radiotherapy (EBRT). Recently, clinical trials are in progress to cure RB without ENU or EBRT in order to salvage the globe and to avoid unacceptable side effects of EBRT. We performed a pilot study to treat patients with advanced Reese-Ellsworth (RE) stage IO RB with initial chemotherapy...