What we know: Sensitisation to indoor allergens (house-dust mite, cat) is related to the level of exposure to these allergens in early childhood. The prevalence of asthma in childhood is independent of allergen exposure in early life. Asthma occurs in a substantial number of young children in the absence of allergen sensitisation. Asthma and allergic sensitisation have increased in recent decad...

Children with asthma can experience chronic morbidity that may interfere with education and career progression. The authors investigated retrospectively whether a history of childhood asthma is associated with educational level and longest-held occupation, by gender. Cross-sectional analysis included a nationally representative sample of 10,452 adults aged 20 years who participated in the US Na...

Background Asthma is one of the most important childhood diseases in developing countries. The prevalence, mortality, and economic burden of the disease have taken a rising trend since 1960, and this increase was more marked in children. The presents study aimed to assess the prevalence of asthma symptoms diagnosed by International Study of Asthma and Allergies in Childhood (ISAAC) questionnair...

Children with asthma can experience chronic morbidity that may interfere with education and career progression. The authors investigated retrospectively whether a history of childhood asthma is associated with educational level and longest-held occupation, by gender. Cross-sectional analysis included a nationally representative sample of 10,452 adults aged ≥20 years who participated in the US N...

BackgroundStudies indicate that the nasal microbiome may correlate strongly with presence or future risk of childhood asthma.ObjectivesIn this study, we tested whether developmental trajectories nasopharyngeal in early life and composition during illnesses were related to asthma.MethodsChildren participating Childhood Origins Asthma study (N = 285) provided mucus samples first 2 years life, rou...

Background & Aims: Asthma is a chronic inflammatory disease of the airways which is associated with the triad of cough, wheezing and dyspnea. Allergic asthma is often associated with a personal or family history of allergic diseases and mostly begins at early childhood. Mold is one of the most common irritants of asthma and allergic rhinitis. In the last 20 years there has been 30% increase in ...

RATIONALE Bronchiolitis during infancy is associated with an increased risk of childhood asthma. Whether winter viral infections cause asthma or are a manifestation of a predisposition to asthma development is unknown. OBJECTIVES To study the relationship of winter virus infection during infancy and the development of childhood asthma. METHODS We studied over 95,000 infants born between 199...

What we know: The outcome of childhood asthma is dependent on the pattern of asthma through childhood. Episodic asthma in childhood tends to resolve in adolescence and through mid-adult years, with no impairment of lung function. Persistent asthma in childhood is more likely to persist into adult years, with modest impairment of lung function. The impairment of lung function occurs early in the...

Asthma in childhood is a heterogeneous disease with different phenotypes and variable clinical manifestations, which depend on the age, gender, genetic background, and environmental influences of the patients. Several longitudinal studies have been conducted to classify the phenotypes of childhood asthma, on the basis of the symptoms, triggers of wheezing illness, or pathophysiological features...

Asthma has become the most common chronic disease in childhood. Significant advances in epidemiological research as well as in therapy of pediatric asthma have been made over the past 2 decades. In this review, we look at certain aspects therapy of childhood asthma, both in the past and present. Literature review on allergen avoidance (including mites, cockroach and cat), intensive therapy with...