CHIR-AB1 is a newly identified avian immunoglobulin (Ig) receptor that includes both activating and inhibitory motifs and was therefore classified as a potentially bifunctional receptor. Recently, CHIR-AB1 was shown to bind the Fc region of chicken IgY and to induce calcium mobilization via association with the common gamma-chain, a subunit that transmits signals upon ligation of many different...

In mammals, the cell surface receptors encoded by the leukocyte receptor complex (LRC) regulate the activity of T lymphocytes and B lymphocytes, as well as that of natural killer cells, and thus provide protection against pathogens and parasites. The chicken genome encodes many Ig-like receptors that are homologous to the LRC receptors. The chicken Ig-like receptor (CHIR) genes are members of a...

Forests are valuable natural resources, beneficial for the storage of carbon, production oxygen, protection soil and controlling water cycle. Despite forests providing different services to environment, they being destroyed at an alarming pace. Forest cover change in Murree, Pakistan over past few years has created climatic issues. There was a research gap on detection forest along with climate...

Evergreen forest communities distributed within 1580-2600 m above sea level (asl) in Kumaun Himalaya were studied. Quercus leucotrichophora A. Campus, Q. floribunda Lindl. ex Rehder Q. semecarpifolia J.E. Smith and Pinus roxburghii Sarg. are the dominant tree species in banj-oak, tilonj-oak, kharsu-oak and chir-pine forests, respectively. Total density for tree, shrub and herb layer varied from...

The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising antibiotic target. CHIR-090, the most potent LpxC inhibitor discovered to date, displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. In this study, we re...

ABSTRACT Microhabitat factors associated with the habitat of barking deer (Muntiacus vaginalis) were examined and compared between summer winter seasons. Habitat characteristics preferred measured by locating direct indirect signs. To quantify utilization deer, each selected study site was sampled for floral diversity from 2015 to 2017. Quadrats deployed along transect lines determine seasonal ...

1 Land use land cover (LULC) patterns are significantly effecting the urban/rural spaces in the encompassing areas. Murree being tourist resort is always under pressure of tourists from all over the country. The population increase in peak season of tourism in summer season and extreme winter, causes a tremendous growth and expansion of urban area of Murree. So a relic of blue pine forest and C...

The Chir Pine, Pinus roxburghii, named after William Roxburgh, is a pine native to the Himalaya. Pinus roxburghii Sarg. (Pinaceae) is traditionally used for several medicinal purposes in India. As the oil of the plant is extensively used in number of herbal preparation for curing inflammatory disorders, the present study was undertaken to assess analgesic and anti-inflammatory activities of its...