6-prenylnaringenin (6pn) is a chiral prenylflavonoid found most prevalently in hops ( humulus lupulus ) and present in hops and hop products. it is an isomer of the potent phytoestrogen, 8-prenylnaringenin. an enantiospecific method for quantitation 6pn by lc-esi-ms has been developed. baseline enantiomeric resolution of 6pn was attained on a chiralpak ® ad-rh column with an isocratic mobile ph...

6-Prenylnaringenin (6PN) is a chiral prenylflavonoid found most prevalently in hops (Humulus lupulus) and present in hops and hop products. It is an isomer of the potent phytoestrogen, 8-prenylnaringenin. An enantiospecific method for quantitation 6PN by LC-ESI-MS has been developed. Baseline enantiomeric resolution of 6PN was attained on a Chiralpak(®) AD-RH column with an isocratic mobile pha...

Although thalidomide was withdrawn due to teratogenicity and neuropathy, there is now growing clinical interest in this compound because of its immunomodulatory and anti-angiogenic properties. In 1998, thalidomide was approved by the U.S. Food and Drug Administration for the treatment of erythema nodosum leprosum (ENL), an inflammatory complication of Hansen's disease, through a restricted-use ...

A high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS) method was established for the separation and determination of acetyl-glutamine enantiomers (acetyl-L-glutamine and acetyl-D-glutamine) simultaneously. Baseline separation was achieved on Chiralpak AD-H column (250 mm × 4.6 mm, 5 µm). n-Hexane (containing 0.1% acetic acid) and ethanol (75:25, v/v) were used as mob...

A simple and rapid chiral liquid chromatographic method was developed for the enantiomeric separation of Sertraline hydrochloride (cis-(1S, 4S)-4-(3, 4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride) and its undesired cis-enantiomer (cis(1R, 4R)-4-(3, 4-dichlorophenyl)-N-methyl-1,2,3,4tetrahydronaphthalen-1-amine hydrochloride). Superior resolution between Sertralin...

The aim of this paper was to validate an analytical method for the simultaneous determination of PTX and its active metabolite (-)-(R)-M1 in rat serum and some tissues using a high-performance liquid chromatography method with ultraviolet detection (HPLC-UV). The specificity, linearity, precision, accuracy, recovery, lower limit of detection, lower limit of quantification and stability study we...

A simple, rapid, specific and precise liquid chromatography—tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for the quantification of chiral separated R-bicalutamide from S-bicalutamide, in human plasma. Topiramate (TPM) was used as internal standard, added to plasma sample prior to extraction using t-butyl methyl ether (TBME). Chromatographic separation was achieve...

2012 ACKNOWLEDGMENTS I would like to thank all people which have made this work possible. I express my sincere gratitude to my supervisor, Professor Militon Frent¸iu, for his help during these years. I also thank Professor Horia F. Pop for research opportunities offered and valuable ideas. The passion for research, encouragements and many ideas came from my coleague Andreea Vescan to whom I am ...

An economic model of the online advertising market is presented, focusing on the effect of ad fraud. In the model, the market is comprised of three classes of players: publishers, advertising networks, and advertisers. The central question is whether ad networks have an incentive to aggressively combat fraud. The main outcome of the model is to answer this question in the affirmative.