Abstract (R)-Tenofovir phenyl ester ((R)-1) and (R)-tenofovir diphenyl ((R)-2) are key intermediates for the practical synthesis of tenofovir alafenamide fumarate, which is a mainstay antiretroviral treatment chronic hepatitis B HIV-1 infections. This article deals with chiral analysis (R)-1 (R)-2 against their respective optical impurity (S)-tenofovir ((S)-1) ((S)-2) using polysaccharide-coate...

Naringenin and eriodictyol are chiral flavanones widely present in citrus fruits and herbal products. Pharmacological interest in the two flavanones is well known. Due to the chiral carbon atom, the compounds always exist in the racemic form. The present study reported a stereospecific HPLC method for the enantioseparation of naringenin and eriodictyol, which was performed on an amylase-based c...

SHORTENED TITLE: HPLC resolution of cis-and trans-β-phenylproline ABSTRACT The preparation of all four stereoisomers of the proline analogue that bears a phenyl group attached to the β carbon either cis or trans to the carboxylic acid (cis-and trans-β-phenylproline, respectively) has been addressed. The methodology developed allows access to multigram quantities of the target amino acids in ena...

A simple analytical high-performance liquid chromatography (HPLC) method was applied for the enantiomeric excess determination of esomeprazole ((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separation was accomplished on the immobilized-type Chiralpak ID-3 chiral stationary phase (CSP) under ...

normal 0 false false false en-us x-none ar-sa background: alzheimer's disease (ad) is a progressive neurodegenerative disease in which endothelial cell (ec) can be affected. in brain, functional changes in ecs contribute to reductions in resting blood flow. furthermore, angiotensin-converting enzyme inhibitors (ace-i) have beneficial effects on endothelial dysfunction. this is the first study t...

alzheimer’s disease (ad) is the most common form of dementia in the elderly in which interplay between genes and the environment is supposed to be involved. mitochondrial dna (mtdna) has the only non-coding regions at the displacement loop (d-loop) region that contains two hypervariable segments (hvs-i and hvs-ii) with high polymorphism. mtdna has already been fully sequenced and many subsequen...

An accurate, simple and reproducible high-performance liquid chromatographic (HPLC) method has been developed and validated for the direct separation of individual enantiomers of Abacavir sulfate, a nucleoside reverse transcriptase inhibitor for the treatment of HIV, in pharmaceutical bulk drugs. The enantiomers were resolved by normal phase chromatography, on Chiralpak IA column by using a mob...

A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine...