Abstract Anopheles stephensi mosquitoes share urban breeding sites with Aedes aegypti and Culex quinquefasciatus in the Republic of Djibouti. We present evidence that A. might be responsible for an increase malaria incidence this country. also document resistance Plasmodium falciparum to dihydroartemisinin/piperaquine.

background: molecules expressed on the surface of infected erythrocytes (ie) with plasmodium falci-parum play important roles in malaria pathogenesis and immune evasion. some of these molecules are specific adhesive ligands mediating adhesion of ie to the vascular endothelium. in the current study, the antigens exposed on the surface of ie with different isolates and various binding subpopulati...

Fourteen plant species collected in Iran and selected mainly on the basis of their antimicrobial and/or antifungal activities were evaluated for in vitro antiplasmodial and cytotoxic effects in a study designed to screen plant extracts with selective activity against Plasmodium falciparum. The methanol extracts of nine of the species tested exhibit activity against Plasmodium falciparum (MIC va...

Malaria is an infectious disease caused by the genus Plasmodium such as Plasmodium falciparum (P. falciparum), Plasmodium ovale, Plasmodium vivax and Plasmodium malariae. Among them, P. falciparum is the parasite responsible for most severe diseases and fatal cases, which may kill over one millions of people per annum. The parasite, P. falciparum is genetically diverse and has multiple independ...

background: electrolytes play an important role in the normal functioning of human body. electrolyte imbalance and mineral disturbances is the common clinical manifestation in several infectious diseases including malaria. malaria is a mosquito borne serious infectious disease of the world. plasmodium vivax and p. falciparum are the main agents responsible for malaria in pakistan. electrolyte i...

Emergence of drugs resistant strains of Plasmodium falciparum has augmented the scourge of malaria in endemic areas. Antimalaria drugs act on different intracellular targets. The majority of them interfere with digestive vacuoles (DVs) while others affect other organelles, namely, apicoplast and mitochondria. Prevention of drug accumulation or access into the target site is one of the mechanism...

background: aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. this study investigated some new aurones derivatives against chloroquine sensitive plasmodium falciparum. here we report the synthesis , in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2...

The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics Abstract Background: The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr and dhps gene mutations are known to be associated with sulphadoxine...