BACKGROUND Alzheimer's disease (AD) is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages. As no safe and effective drug is yet available for the treatment of AD, secondary metabolites from plants may be instrumental in meeting this challenge. Keeping in view this point we evaluated sesquiterpenes of medicinal plant Amberboa ramosa for thei...

Smyrnium connatum Boiss. and Kotschy is known as “yabani kereviz” in Turkey its roots are used to treat asthma. species by people different regions diuretic, depurative laxative. The aim of this analysis was test the biological activities methanol extracts obtained from aerial parts S. using a Soxhlet extractor, ultrasonic assisted extraction, maceration procedures. were tested for their acetyl...

The inhibitory effect of (+/-) propranolol 1.69 x 10(-4)-1.69 x 10(-7) mol litre-1 on normal and atypical plasma cholinesterase variants was investigated. The atypical enzyme is less sensitive to inhibition by (+/-) propranolol or either of its enantiomorphs than the usual enzyme. Propranolol 8.45 x 10(-6) mol litre-1 was used as differential inhibitor of 643 plasma samples from individuals of ...

伴 隆志 ・永田 親 義 The inhibition of cholinesterase by some of carbamates has attracted the attention of many researchers in relation to the clinical usefulness (1) and insecticidal activity (2, 3) of the compounds. In this paper the author's chief concern is mainly devoted to investigating the rela tionship between the electronic structure of several structurally related carbamate type cholinesteras...

We have developed a succinyldicholine-based assay for serum cholinesterase (EC 3.1.1.8) to help establish whether patients with suspected sensitivity to drugs of this type have enzyme abnormalities that cannot be detected by conventional laboratory techniques. Although the method discriminates between cholinesterase activities of drug-sensitive and nonsensitive people as well as an assay involv...

A series of twelve nature-inspired 3,4,5-trimethoxycinnamates were prepared and characterized. All compounds, including the starting 3,4,5-trimethoxycinnamic acid, tested for their ability to inhibit acetylcholinesterase (AChE) butyrylcholinesterase (BChE) in vitro; selectivity index (SI) was also determined. 2-Fluororophenyl (2E)-3-(3,4,5-trimethoxyphenyl)-prop-2-enoate demonstrated highest SI...

Phytochemicals found in extracts obtained from plants are very important bioactive constituents. In this study, phytochemicals extract content Celtis tournefortii .Lam. tree (CT) leaves were determined by a LC-MS method. The constituents with the major concentrations was rutin (2479.89 µg ml-1), coumarin (1241.68 biochanin A (1026.42 shikimic acid (477.32 chlorogenic (300.76 ml-1). suppressive ...