A considerable body of literature indicates that on monolayer culture, embryonic chick cartilage cells are obtained which morphologically and biochemically behave as chondrocytes (1). Earlier studies suggested that repeated monolayer culture results in "dedifferentiation" of chondro-434 B R I E F N 0 T E S cytes to give fibroblast-like cells. Coon (2) has demonstrated that with appropriate medi...

Endochondral bone formation is a highly orchestrated process involving coordination among cell-cell, cell-matrix and growth factor signaling that eventually results in the production of mineralized bone from a cartilage template. Chondrogenic and osteogenic differentiation occur in sequence during this process, and the temporospatial patterning clearly requires the activities of heparin binding...

SKI306X was previously found to have cartilage protective effects in the experimental osteoarthritis (OA) model. To investigate the chondro-protective benefits of SKI306X for its capacity in altering changes in cartilage metabolism and molecular mechanisms of cartilage protective action, SKI306X is studied in rabbit cartilage explants culture. To investigate the protective effect of SKI306X on ...

BACKGROUND This study aimed to determine whether intra-articularly injected adipose-derived stem cells (ADSCs) inhibited articular cartilage degeneration during osteoarthritis (OA) development in a rabbit anterior cruciate ligament transection (ACLT) model. The paracrine effects of ADSCs on chondrocytes were investigated using a co-culture system. METHODS ACLT was performed on both knee joint...

Reconstruction of the external ear is a challenging problem encountered by plastic surgeons. Causes deformities can be various etiologies (human bites, animal fights, burns, infections, accidents, or even sports injuries). Full-thickness defects, which cannot treated approximating wound edges, show good results with Antia-Buch’s chondro-cutaneous flaps. A 34-year-old male presented history huma...

Articular cartilage is a soft tissue showing inelastic properties. Under cyclic loading, inelastic materials may dissipate mechanical energy into heat. In knee cartilage, due to an intrinsic reduced heat convection related to its avascularity, a local temperature increase could be observed. This phenomenon is referred to as self-heating. As cells are sensitive to temperature variation, the ener...

A principle of reconstructive surgery is to replace lost tissue with similar tissue. This principle is applicable particularly to traumatic and orthopaedic surgery in which autografts are now used widely to replace bone, tendon, nerve and skin. Articular cartilage, as a component of a synovial joint, is rarely transplanted as an autograft in man. When used as an autograft articular cartilage is...

OBJECTIVES The utility of autologous chondrocytes for cartilage repair strategies in older subjects with osteoarthritis (OA) may be limited by both age-related and disease-associated decline in chondrogenesis. The aim of this work was to assess OA Hoffa's fat pad as an alternative source of autologous chondroprogenitor cells and to compare it with OA chondrocytes derived from different areas of...

Purpose: The objects of this study were to compare biological properties of a native articular cartilage extracellular matrix (ACECM)-derived oriented scaffold and the Chondro-Gide bilayered scaffold. Methods: The ACECM oriented scaffold (No. 4131) and the Chondro-Gide scaffold (No. 4132) compared form (I) The physical properties (II) FDA/Pl staining, and frozen sections were stained with tolui...