The choroid plexus is an important central nervous system (CNS) structure that is often neglected in pathologic and radiologic studies of intracranial diseases. The choroid plexus may serve as 1) a portal of entry for pathogens into the CNS, 2) a target for various systemic disorders, 3) a reflector of various diseases that affect the brain and meninges, or 4) a site of primary processes such a...

Choroid plexus cysts are rare lesions in the brain and are reported in humans and dogs. Herein, we report a choroid plexus cyst found in a 10-week-old female Sprague-Dawley rat. Histologically, a cyst measuring approximately 600 μm in diameter was found in the fourth ventricle of the brain. The cyst was lined with a single layer of flattened cells and was present in the connective tissue of the...

125I-Lysergic acid diethylamide (125I-LSD) binds with high affinity to serotonergic sites on rat choroid plexus. These sites were localized to choroid plexus epithelial cells by use of a novel high resolution stripping film technique for light microscopic autoradiography. In membrane preparations from rat choroid plexus, the serotonergic site density was 3100 fmol/mg of protein, which is 10-fol...

The goal of this study was to examine humoral mechanisms that regulate blood flow to the choroid plexus. We determined the effects of arginine vasopressin on blood flow (microspheres) to the choroid plexus in anesthetized and awake rabbits. In anesthetized rabbits, blood flow to the choroid plexus was 342 +/- 31 (mean +/- SEM) ml/min/100 g under control conditions. Intravenous infusion of vasop...

Choroid plexus papillomas are rare, benign tumors originating from the choroid plexus. Although generally found within the ventricular system, they can arise ectopically in the brain parenchyma or disseminate throughout the neuraxis. We sought to review recent advances in our understanding of the molecular biology and oncogenic pathways associated with this disease. A comprehensive PubMed liter...

The choroid plexus epithelium is a secretory epithelium par excellence. However, this is perhaps not the most prominent reason for the massive interest in this modest-sized tissue residing inside the brain ventricles. Most likely, the dominant reason for extensive studies of the choroid plexus is the identification of this epithelium as the source of the majority of intraventricular cerebrospin...

Primary cultures of rat choroid plexus epithelial cells were established and used to investigate the role of the choroid plexus in the synthesis and secretion of transferrin. Transferrin gene expression was determined by a Northern blot analysis with a transferrin cRNA probe. A single transferrin mRNA species was detected and found to be the same size as the transcripts in the liver and Sertoli...

BACKGROUND Research shows that there is an association between choroid plexus cysts and aneuploidy. Family physicians treating prenatal patients should understand the management of this sonographic finding. OBJECTIVE To determine the epidemiology, pathophysiology, and management of prenatal choroid plexus cysts. CASE REPORT A 23-year-old patient, gravida 1, para 0, was seen at an inner city...

We report two neutropenic patients with Stomatococcus mucilaginosus meningitis and choroid plexus involvement on neuroimaging studies. CT and MR showed abnormal enlargement of the choroid plexus in one lateral ventricle and intense enhancement. In one patient there was edema in the periventricular white matter adjacent to the involved choroid plexus; in both patients there was enhancement of th...

CPCs are a relatively common finding during the second trimester sonography. when a choroid plexus cyst is identified, the presence of structural malformation and other sonographic markers of aneuploidy should be assessed with a detailed fetal anatomic survey performed by an experienced person. if no other sonographic abnormalities are present, the CPC is considered isolated. given the consider...