نتایج جستجو برای: choroidal neovascularization

تعداد نتایج: 17766  

Journal: :Investigative ophthalmology & visual science 2002
Nahoko Ogata Mitsumasa Wada Tsuyoshi Otsuji Nobuo Jo Joyce Tombran-Tink Miyo Matsumura

PURPOSE Pigment epithelium-derived factor (PEDF) is a protein produced by the retinal pigment epithelial (RPE) cells. Recent studies have implicated PEDF in activities that are inhibitory to angiogenesis. In this study, the expression of PEDF was investigated in normal rat eyes and in eyes with experimentally induced choroidal neovascularization and compared with the expression of vascular endo...

Journal: :بینا 0
سیدمهدی مدرس زاده m modareszadeh دانشگاه علوم پزشکی ایران

age related macular degeneration (amd) is the most common cause of visual impairment in the population above 64 years of age in developed countries. most cases of severe vision loss due to amd are caused by exudative changes in the macula. extensive research on amd has led to advances in its prophylaxis and treatment in recent years. photodynamic therapy (pdt) was developed in late 1990's ...

2017
Halesha D Basavarajappa Rania S Sulaiman Xiaoping Qi Trupti Shetty Sardar Sheik Pran Babu Kamakshi L Sishtla Bit Lee Judith Quigley Sameerah Alkhairy Christian M Briggs Kamna Gupta Buyun Tang Mehdi Shadmand Maria B Grant Michael E Boulton Seung-Yong Seo Timothy W Corson

Ocular neovascularization underlies major blinding eye diseases such as "wet" age-related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and refractory patient populations necessitate discovery of new therapeutic targets. Using a forward chemical genetic approach, we identified the heme synthesis enzyme ...

2015
Yan Gong Jie Li Ye Sun Zhongjie Fu Chi-Hsiu Liu Lucy Evans Nicholas Saba Thomas Fredrick Peyton Morss Jing Chen Lois E. H. Smith

2006
Henry J. Kaplan Puran S. Bora Qin Xu Jeong-Hyeon Sohn Dhara B. Dhaulakhandi Nalini S. Bora Sankaranarayanan Kaliappan Purushottam Jha

Journal: :Arquivos brasileiros de oftalmologia 2005
Hugo Soares Maia Remo Turchetti Moysés Zajdenweber Oswaldo Ferreira Moura Brasil

We report the use of photodynamic therapy with verteporfin for subfoveal choroidal neovacularization in central serous chorioretinopathy. Visual acuity improved (0.5 to 1.0) 30 days after the first session. After 141 days, the choroidal neovascularization reactivated and the patient was retreated. Again, visual acuity improved (0.5 to 1.0) 30 days afterwards. It remains stable after 20 months. ...

Journal: :Investigative ophthalmology & visual science 2017
Yasuo Yanagi Aditi Mohla Won-Ki Lee Shu Yen Lee Ranjana Mathur Choi Mun Chan Ian Yeo Tien Yin Wong Chui Ming Gemmy Cheung

Purpose To determine the prevalence of subclinical nonexudative neovascularization and associated choroidal vascular changes in the fellow eyes of patients presenting with unilateral typical exudative AMD (tAMD) or polypoidal choroidal vasculopathy (PCV) using indocyanine green angiography (ICGA) and swept-source (SS) optical coherence tomography angiography (OCT-A). Methods We recruited pati...

Journal: :Archives of ophthalmology 2003
Mitchell J Goff John B Kerrison

tion With Photodynamic Therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials—TAP Report 1 [published correction appears in Arch Ophthalmol. 2000;118:488]. Arch Ophthalmol. 1999; 117:1329-1345. 2. Verteporfin in Photodynamic Therapy Study Group. Verteporfin t...

Journal: :Investigative ophthalmology & visual science 1999
Y Takehana T Kurokawa T Kitamura Y Tsukahara S Akahane M Kitazawa N Yoshimura

PURPOSE To determine whether tranilast administered to pigmented rats inhibits formation of choroidal neovascularization induced by diode-laser photocoagulation. METHODS Female Brown Norway rats were used. On day 0, choroidal neovascularization was induced by diode-laser photocoagulation, using a setting of 75 microm spot size, 0.1 second's duration, and 100 mW intensity. Tranilast (200 or 60...

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