Mice with X-linked chronic granulomatous disease (CGD) generated by targeted disruption of the gp91phox subunit of the NADPH-oxidase complex (X-CGD mice) were examined for their response to respiratory challenge with Aspergillus fumigatus. This opportunistic fungal pathogen causes infection in CGD patients due to the deficient generation of neutrophil respiratory burst oxidants important for da...

in chronic granulomatous disease (cgd) patients, esophageal stricture is a rare complication and the treatment of choice is still controversial. there are few reports of successful therapy with antibiotics, corticosteroids, multiple balloon dilatations or their combination. we report a 3-three-year-old iranian boy with recurrent esophageal obstruction due to cgd. the patient transiently respond...

Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent, life-threatening bacterial and fungal infections of the skin, airways, lymph nodes, liver, brain, bones. These most commonly occur in organs contact with outside world (lungs, gastrointestinal tract, skin), as well nodes that drain these structures. While involvement can be seen many organs, there no k...

An 8-month-old boy developed a necrotic lung mass from which Burkholderia glumae was recovered, leading to the diagnosis of chronic granulomatous disease (CGD). While other Burkholderia species have been identified as important pathogens in persons with CGD, B. glumae has not been previously reported to cause human infection.

Antibiotic prophylaxis in patients with chronic granulomatous disease (CGD) has decreased the prevalence of infections, but uncommon microorganisms are being observed more frequently. Propionibacterium acnes, a saprophyte of the skin, is generally not involved in infections other than acne. Two cases of P. acnes extracutaneous infections in teenagers with CGD are reported.

Background Chronic Granulomatous Disease (CGD) is an inherited deficiency which results from the absence or dysfunction of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in phagocytic cells. This condition is usually diagnosed in early childhood and presents with recurrent infections at epithelial surfaces such as the skin, lungs, and gut. We present a case of CGD which wa...

In a patient suffering from X-linked chronic granulomatous disease (X-CGD)--a disorder of phagocytesuperoxide generation--and McLeod syndrome, characterized by the absence of the red cell Kell antigen, we identified a deletion of the entire X-CGD gene by means of DNA hybridization with a cDNA probe. Our findings suggest that the X-CGD and McLeod loci are physically close in the p21 region of th...

Chronic granulomatous disease (CGD) is caused by a congenital defect in phagocyte reduced nicotinamide dinucleotide phosphate (NADPH) oxidase production of superoxide and related species. It is characterized by recurrent life-threatening bacterial and fungal infections and tissue granuloma formation. We have created a mouse model of CGD by targeted disruption of p47p h~ one of the genes in whic...