800x600 hepatitis b virus (hbv) infection is the main cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma (hcc). several factors such as serum hbv dna level, genotype and specific viral mutations have been clarified to determine disease progression of chronic hepatitis b. among these, mutations can also occur in chronic hbv patients with antiviral treatment such as lamivudine the...

Chronic hepatitis B is still a major public health issue despite the successful prophylactic vaccination attempts. Chronicity of hepatitis B virus(HBV) is mainly due to its ability to debilitate host's immune system. Therefore, major measures have been taken to stop this process and help patients with chronic hepatitis B infection recover from their illness. While satisfactory results have been...

results findings showed that the genotype -607a/a is associated with the susceptibility to chronic hepatitis b. furthermore, allele c at position -137 is suggested to play a protective role against development of chronic hbv infection. conclusions host genetic factors play an important role in determining the outcome of hbv infection. it is suggested that il-18 genotype -607 a/a is associated w...

Hepatitis B virus (HBV) covalently closed circular (CCC) DNA is the source of HBV transcripts and persistence in chronically infected patients. The novel aspect of this study was to determine the effect of RNA interference (RNAi) on HBV CCC DNA when administered prior to establishment of HBV replication or during chronic HBV infection. HBV replication was initiated in HepG2 cells by transductio...

OBJECTIVE The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding of HBV strain distribution and transmission risk. METHODS HBV surface antigen (HBsAg) positive samples of acute (n = 152) and chronic (n = 1533) HBV submitted for strain analysis or reference genotype testing between 2006 and 2012 w...

chronic hepatitis b is still a major public health issue despite the successful prophylactic vaccination attempts. chronicity of hepatitis b virus(hbv) is mainly due to its ability to debilitate host's immune system. therefore, major measures have been taken to stop this process and help patients with chronic hepatitis b infection recover from their illness. while satisfactory results have...

background: toll- like receptors (tlrs) play an important role in the recognition of damps and pamps and induction ofinflammation. previous studies demonstrated that depression and anxiety can influence the expression levels of immune related molecules. our previous study revealed that mrna levels of irak4, traf3 and irf7 were significantly decreased in chronic hbv infected (chb) patients when ...

introduction: the hepatitis b is a viral infection that causes a big problem globally. about 2 billion people worldwide are infected and there are now about 400 million hbv-dna carriers around the world. hbv infection is the ninth cause of death worldwide and infects about 350 million new cases each year in the world. hbv-dna can be spotted in different body secretions and fluids, including ser...

Given the shared risk factors for transmission, coinfection with hepatitis B virus (HBV) and HIV is common. HIV infection increases the risk of chronic HBV infection and hastens the progression of liver disease in patients with chronic HBV infection. The treatment of chronic HBV infection needs to be carefully coordinated with HIV management in HBV-HIV coinfected patients. The main goals of tre...

Cytogenetic analysis of metaphase chromosome spreads from peripheral blood cells of hepatitis B virus (HBV) chronic carriers and HBV-negative individuals of the same ethnic origin revealed a significantly higher incidence of chromosome breaks and other mitotic aberrations in the HBV chronic carriers. The highest incidence of chromosome breaks was found in chronic carriers who evidenced circulat...