Background Autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. Most of the cases are associated with viral or bacterial infections. In some cases, AIHA can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. Case report Especially in children younger...

Hemolysis can saturate the hemoglobin (Hb)/heme scavenging system, resulting in increased circulating cell-free Hb (CF-Hb) in hereditary and acquired hemolytic disease. While recent studies have suggested a central role for intravascular hemolysis and CF-Hb in the development of vascular dysfunction, this concept has stimulated considerable debate. This highlights the importance of determining ...

The hallmark of hemolysis is shortened red blood cell survival in the peripheral blood. Hemolysis results in anemia only when bone marrow cannot keep up with the rate of red cell destruction. Even though anemia is very commonly observed in most cancer patients, hemolytic anemias are rather rare. Acute or chronic hemolysis, when present can impact on quality of life adversely, especially when bo...

AIM Deficiency in vitamin E, a natural antioxidant, participates in abnormal erythrocyte membrane lipids, structural alterations and hemolysis in advanced cirrhosis. Poor absorption of fat-soluble vitamins limits full correction of deficiency with standard formulations in cirrhosis with cholestasis. The aim of the present study was to examine safety and effects of tocofersolan, a water-soluble ...

The enzymatic properties of a new glucose-6-phosphate dehydrogenase (G-6-PD) variant (G-6-PD Long Prairie) were studied in a white patient with chronic nonspherocytic hemolysis. The red cells were found to have 2.3%-7.7% normal enzymatic activity. The mutant enzyme exhibited marked heat instability, an increased pH optimum, a moderately decreased Km for G-6-P, and increased utilization of 2-deo...

We studied the effect of chronic oral exposure to lead acetate (PbA) on the sensitivity of RBC to hemolysis and whether the sensitivity could be decreased by feeding the rats with extract of medicinal mushroom Ganoderma lucidum. Three groups of rats, control, PbA-exposed, and G. lucidum (Gl)+PbA, were used. PbA (3 mM) was administered via drinking water and G. lucidum extract by gavage at 300 m...

background autoimmune hemolytic anemia is a hematologic disorder that is rarely observed in infants and young children. most of the cases are associated with viral or bacterial infections. in some cases, aiha can be characterized by a chronic course and an unsatisfactory control of hemolysis, thus requiring prolonged immunosuppressive therapy. case report especially in children younger than 2 y...

By J. V. DAdE, M.B., M.R.C.P. LONDON H YDROGEN ion concentration has a controlling effect upon many hemolytic systems, both simple and complex. Osbor& in 1934 reviewed the early literature on the effect of pH on the hemolysis by complement of corpuscles sensitized by hemolytic immune body. He found that the optimum reaction for the hemolysis of sheep corpuscles by guinea pig serum was about pH ...

It is widely accepted and clinically anticipated that the patient implanted with a mechanical circulatory assist device (MCAD) will develop a state of chronic anemia that will last throughout the duration of MCAD support. Large-scale hemolysis mediated by the high sheer stress transmitted to the erythrocytes (RBCs) from the mechanical action of most MCAD systems is the accustomed mechanism resp...