conclusions the results indicated that there was a positive association between susceptibility to chronic hbv infection and tnf-α polymorphism. in addition, hbv patients carrying -308 gg, -857 cc, and -863 aa genotypes with lower serum levels of tnf-α had an increased risk of infection. background the host genetic background regulates the natural history of chronic hepatitis b virus (hbv) infec...

results findings showed that the genotype -607a/a is associated with the susceptibility to chronic hepatitis b. furthermore, allele c at position -137 is suggested to play a protective role against development of chronic hbv infection. conclusions host genetic factors play an important role in determining the outcome of hbv infection. it is suggested that il-18 genotype -607 a/a is associated w...

Background: To determine the possible sources for the transmission of Hepatitis B Virus (HBV) infection to children in Babol, North of Iran.Methods: Forty-five boys and 35 girls with the mean age of 9.2±5.1 years were evaluated from 1993 to 2004. Hepatitis B viral markers in all the family members were assessed. The risk factors for other sources were also determined.Results: Sixty-five (81.3%)...

this study was undertaken to define the prevalence of the upper gastrointestinal (gi) lesions, dyspeptic symptoms, h.pylori infection, and the impact of duration of dialysis on upper gi symptoms and lesions of children with end-stage renal disease. we studied 69 children with esrd who were under regular hemodialysis therapy in our department. the age of the patients were between 4-18 years (mea...

background: idiopathic thrombocytopenic purpura is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. there are two forms of itp: acute and chronic. the aim of the present study was to evaluate the clinical variables in adult patients with acute itp in west of iran. patients and methods: medical records of adult patients with diagnosis of acute i...

Background: There are two forms of ITP: acute and chronic. The chronic form is defined by persistent thrombocytopenia for more than 12 months and mostly occurs among young women. The aim of the present study was to evaluate the clinical variables in adult patients with chronic ITP in West Iran. Patients and Methods: Between of 2007 and 2014, ninety adult patients with chronic ITP referred to...

abstract   background: hepatitis b virus infection is an important cause of liver morbidity and mortality worldwide. hdv changes the natural course of hbv. the prevalence of hdv infection wasn’t determined in the various groups of hbv infection (carriers, acute hepatitis, chronic hepatitis, cirrhosis and hcc) in iran. we aimed to research the prevalence of hepatitis d virus infection in various...

conclusions to our knowledge, this is the first chronic case confirmed by the prolonged presence of hev rna in china. it is also the first reported persistent hepatitis e infection caused by hev genotype 4. case presentation here we report a chinese boy with acute lymphoblastic leukemia, who developed hepatitis e during a period of intensive chemotherapy. twenty months after the initial infecti...

chronic granulomatous disease is an inherited defect in intracellular killing of ingested microorganisms characterized by recurrent life threatening bacterial and fungal infections including invasive aspergillosis in early childhood. we report  a  disseminated aspergillosis as  the  representative  of  adult  onset  chronic granulomatous disease without previous infection, with dramatic respons...