Chromatins prepared from leukemic lymphosarcoma cell(s), (LS), acute lymphoblastic leukemia cells, chronic lymphocytic leukemia cells and normal tissue culture lymphocytes (NC-37) were studied with respect to their chemical compositions, thermal denaturation profiles, and template activities. Acute lymphoblastic leukemia and LS chromatins had approximately 2 to 4 times the nonhistone protein an...

Chromatins prepared from leukemic lymphosarcoma cell(s), (LS), acute lymphoblastic leukemia cells, chronic lymphocytic leukemia cells and normal tissue culture lymphocytes (NC-37) were studied with respect to their chemical compositions, thermal denaturation profiles, and template activities. Acute lymphoblastic leukemia and LS chromatins had approximately 2 to 4 times the nonhistone protein an...

Lymphocyte-dependent antibodies (LDA's) directed against antigenic determinants present on lymphoblastoid cell lines as well as human leukemia blast cells were demonstrated in heterologous antisera obtained by immunizing rabbits with a membrane fraction from RPMI-4265 (a lymphoblastoid cell line derived from a patient with chronic myelogenous leukemia). LDA was present at high titers against B-...

The terminal phase of most patients with Ph1-positive chronic granulocytic leukemia (i.e., blast crisis) resembles acute leukemia. The clinical and hematologic features of blast crisis in 73 patients with chronic granulocytic leukemia have been reviewed. Two major morphological subgroups, lymphoblastic and myeloblastic, were identified. The lymphoblastic group in general had more profound throm...

OBJECTIVE The aim of this study was to determine the efficiency of the high throughput FISH analysis (HTFA) method for detecting genetic alterations in hematological malignancies, which is a new bacterial artificial chromosome array-based approach. MATERIALS AND METHODS We performed a HTFA study of bone marrow aspiration and peripheral blood samples of 77 cases (n=19 myelodysplastic syndrome,...

Ferroptosis is a newly defined programmed cell death (PCD) process with the hallmark of accumulation iron-dependent lipid peroxidation, which more immunogenic over apoptosis. shows great potential as therapeutic target against acute kidney injury (AKI), cancers, cardiovascular diseases, neurodegenerative and hepatic diseases. Accumulating evidence has highlighted that ferroptosis plays an unneg...

Blast cells were obtained from 17 patients with acute undifferentiated leukemia and 13 patients with chronic myelogenous leukemia in blast crisis. The blasts were tested with anti-i serum in cytotoxicity tests and with antisera to myeloblastic leukemiaassociated antigens in immunofluorescence tests. The terminal deoxynucleotidyl transferase (TDT) content of the blasts was also measured. Lymphob...