Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had s...

PURPOSE Recent work suggested that psychosis might be expressed at subclinical levels. However, the determinants of subclinical psychotic symptoms, the degree of continuity over the life span, and the impact on functioning remain unclear. Thus we analyzed the prevalence, determinants, patterns and impact of subclinical psychotic symptoms in a community cohort over a 20-year period. METHODS Th...

Background: People with psychotic disorders have poor health, but studies shown that people who a milder and more prevalent form of psychosis (psychotic experiences) are also at risk for health problems. More research is needed to examine broad range conditions discover new relations experiences. Methods: We analyzed cross-sectional data from the American Life Panel, nationally representative s...

BACKGROUND Schizophrenia, schizoaffective disorder, and psychotic bipolar disorder overlap with regard to symptoms, structural and functional brain abnormalities, and genetic risk factors. Neurobiological pathways connecting genes to clinical phenotypes across the spectrum from schizophrenia to psychotic bipolar disorder remain largely unknown. METHODS We examined the relationship between str...

OBJECTIVE To estimate the lifetime prevalence of 12 DSM-IV disorders with psychotic symptoms in a general population survey. METHOD Addresses were contacted in a multistage clustered area probability sampling frame of administrative neighbourhoods and households, covering 9 districts and 302 neighbourhoods in the Izmir metropolitan area between November 2007 and October 2008. One household me...

CONTENTS Chapter 1 General introduction 7 Chapter 2 Bone mineral density as a marker of cumulative endogenous estrogen 19 exposure: relationship to background genetic risk of psychotic disorder Chapter 3 Testing the estrogen hypothesis of schizophrenia: associations between 37 cumulative estrogen exposure and cerebral structural measures Chapter 4 Bone mineral density as a marker of cumulative ...

BACKGROUND Detection of psychotic disorders is an important issue, since early treatment might improve prognosis. Timely diagnosis of psychotic disorders depends on recognition of psychotic symptoms and their interpretation. The aim of this study is to examine to what extent reported psychotic symptoms are accounted for in clinical diagnosis. METHODS The medical files of all patients who had ...

Comorbity is very high in posttraumatic stress disorder (PTSD) patients. PTSD is very often complicated with depressive disorder, substance abuse, other anxiety disorders, personality disorders, psychotic features, etc. There have been few pharmacotherapy studies in this complicated field. In the past few years the literature on pharmacotherapy treatment for PTSD and comorbidity has arisen. Fro...

CONTEXT Recent general population surveys of psychotic disorders have found low lifetime prevalences. However, this may be owing to methodological problems. Few studies have reported the prevalences of all specific psychotic disorders. OBJECTIVE To provide reliable estimates of the lifetime prevalences of specific psychotic disorders. DESIGN General population survey. SETTING AND PARTICIP...

UNLABELLED Systemic Lupus Erythematosus (SLE) is autoimmunological disease of connective tissue which is characterized with clinical symptoms of many systems and organs injury. There are often neuropsychiatric symptoms. Psychotic disorder is the least frequent syndrome. Neuropsychiatric symptoms are important because they deteriorate the quality of life and are poor prognostic factor. AIM The...