Use of compounded L-asparaginase became routine in veterinary oncology when manufacturing of Elspar® was discontinued in 2012. The objective of this study was to evaluate the safety of compounded L-asparaginase (CLASP, KRS Global Biotechnology, Boca Raton, FL, USA) in comparison with Elspar® (Lundbeck LLC, Deerfield, IL, USA). In addition, we documented the response to CLASP in combination with...

PURPOSE The purpose of this study was to investigate the dynamic retentive force of a mandibular unilateral distal-extension partial denture framework with a back-action clasp that was designed in a buccally tilted cast on a dental surveyor. The retention mechanism of this framework was analyzed in comparison with other typical unilateral and bilateral frameworks for the mandibular Kennedy clas...

The microtubule (MT) plus-end tracking protein (+TIP) CLASP mediates dynamic cellular behaviors and interacts with numerous cytoplasmic proteins. While the influence of some CLASP interactors on MT behavior is known, a comprehensive survey of the proteins in the CLASP interactome as MT regulators is missing. Ultimately, we are interested in understanding how CLASP collaborates with functionally...

Microtubule (MT) plus-end tracking proteins (+TIPs) preferentially localize to MT plus ends. End-binding proteins (EBs) are master regulators of the +TIP complex; however, it is unknown whether EBs are regulated by other +TIPs. Here, we show that cytoplasmic linker-associated proteins (CLASPs) modulate EB localization at MTs. In CLASP-depleted cells, EBs localized along the MT lattice in additi...

CLASP proteins play crucial roles in regulating microtubules. In this issue of Structure, Leano and colleagues show that an essential and previously cryptic domain of CLASP is a TOG domain with unusual features that might explain its unique functions.

Objective: To determine the pattern of partial edentulism and cast removable dental prosthesis design in relation to Classes recorded.
 Study Design: Cross-sectional study.
 Place Duration Study: Department Prosthodontics, Armed Forces Institute Dentistry (AFID), Rawalpindi Pakistan, from Apr Sep 2021.
 Methodology: A total 67 partially dentate male female patients presenting Pro...

clasp1 combines the high-level modeling capacities of Answer Set Programming (ASP; [1]) with state-of-the-art techniques from the area of Boolean constraint solving. It is originally designed and optimized for conflict-driven ASP solving [2], [3], [4]. Most of its innovative algorithms and data structures, like e.g. ASP-oriented pre-processing [5] or native support of aggregates [6], are thus o...

Epiblast cells CLASP onto the basement membrane N akaya et al. reveal how the microtubule plus-end tracking protein CLASP and the adhesion receptor Dystroglycan combine to regulate epithelial-to-mesenchymal transitions (EMTs) in early embryogenesis. During gastrulation, cells in the primitive streak—part of an epithelial layer called the epiblast—undergo EMT to form the embryonic mesoderm. One ...

CLASP proteins associate with either the plus ends or sidewalls of microtubules depending on the subcellular location and cell type. In plant cells, CLASP's distribution along the full length of microtubules corresponds with the uniform anchorage of microtubules to the cell cortex. Using live cell imaging, we show here that loss of CLASP in Arabidopsis thaliana results in partial detachment of ...

In animals and yeast, CLASP proteins are microtubule plus-end tracking proteins (+TIPS) involved in the regulation of microtubule plus-end dynamics and stabilization. Here we show that mutations in the Arabidopsis CLASP homolog result in various plant growth reductions, cell form defects and reduced mitotic activity. Analysis of Arabidopsis plants that carry a YFP:AtCLASP fusion construct regul...