Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolutionary rate compared with nonclients; however, other factors, such as gene expression and protein connectivity, m...

In psychotherapy, therapists often formulate interpretations of clients' prior talk which are ‘unilateral’ in the sense that index they themselves author an interpretive inference may not be acceptable to client. Based on 100 German-language recordings brief psychodynamic psychotherapy (4 clients with 25 sessions each), we describe a multimodal practice constructing extended multi-unit turns de...

Article history: Received 9 February 2011 Available online 8 July 2011 The current study investigated the role of approach and avoidance motives for unemployed job search behavior. Two approach motives (employment and PJ-fit) and two avoidance motives (low-expectation and low-interest) were distinguished. Antecedents and consequences of these motives were examined using a sample of 303 unemploy...

This study analyzes the pricing of auditors’ business risk in the first year of an audit engagement. We posit that reportable events from the prior auditor’s tenure that are disclosed in the 8-K auditor change filing provide reliable information about the level of business risk for the incoming auditor. We hypothesize that for clients perceived as risky, the incoming auditor charges a fee-premi...

Methods Nurses participated in a series of 3 two hour focus groups (5–9 participants per group; 71% participated in all 3 groups). Research questions were addressed using the nominal group technique. The researcher took field notes during the focus groups. Nurses identified clients whom they thought were empowered through their practice, and consenting clients were interviewed for about 1 hour ...

Business training is an essential part of business development programs (BDPs). Yet, its impact on entrepreneurs’ profits is limited. We develop a theoretical framework where limited effect of business training is due to mismatch between a BDPs’ narrow focus on business-promoting strategies and a wider context in which microfinance clients operate. We assume households have multiple sources of ...

Numerous laboratory experiments document behavior inconsistent with economic models of rational maximization. How much do these inconsistencies matter in natural settings, when consumers make large, real decisions and have the opportunity to learn from experiences? We report on a field experiment designed to address this question. Incumbent clients of a lender in South Africa were sent letters ...

introduction: in any organization particularly in health care centers, the clients' satisfaction provides the conditions to achieve the pre-determined objectives. one of the ways to get the clients' satisfaction is to follow the clients' takrim plan. to this end, in this article, the clients' takrim plan was studied in health centers affiliated with oil industry organization. methods and materi...