Effective diagnostic methods are of great importance in order to recognise myasthenic patients among those with muscle fatigability. Intracellular recordings are useful for research work within the field and for detailed description of the motor end-plate's physiology in the individual case. The method is not used for the routine diagnosis of myasthenia gravis. The decrement of the electrical m...

Electrophysiology, which is the study of electrical properties biological tissues and cells, has become indispensable in modern clinical research, diagnostics, disease monitoring therapeutics. In this paper we present a brief history discipline how integrated circuit design shaped electrophysiology last few decades. We will discuss biopotential amplifier evolved from classical three-opamp archi...