objective: the study aimed to evaluate the effectiveness of laparoscopic ovarian drilling (lod) on ovulation and restoration of menstrual cycles andpregnancy.  materials and m ethods : this cross sectional study was conducted on 81 consecutive polycystic ovarian syndrome (pco) patients whom were referred to  avesina infertility clinic during 2003-2006. exclusion criteria were tubal and male fac...

Patients suffering from normogonadotrophic anovulation and infertility are initially treated with clomiphene citrate. Those who do not respond to clomiphene citrate usually receive gonadotrophin treatment which is labour-intensive, expensive, and associated with an increased risk of multiple pregnancies and ovarian hyperstimulation syndrome. We treated 22 patients with clomiphene resistant norm...

To evaluate gonadotropin release in polycystic ovary syndrome (PCO), one or more of the following hypothalamic-pituitary function tests were performed on 24 patients with the syndrome. These tests included (a) the pulsatile pattern and day-to-day fluctuation of gonadotropin release; (b) effects of exogenous estrogen and antiestrogen (clomiphene) administration on gonadotropin release; and (c) p...

OBJECTIVE This study aimed to compare two methods of treatment of infertility with gonadotropin with laparoscopic ovarian electrocauterization in patients with clomiphene citrate-resistant polycystic ovary syndrome (PCOS). METHODS A number of 104 nulipara patients with polycystic ovary syndrome, who were resistant to clomiphene citrate were randomly assigned to two groups. One group received ...

Medical ovulation induction with clomiphene citrate is currently the first line treatment for anovulatory women PCOS. Clomiphene resistance (failure to ovulate after taking clomiphene) common, occurring in approximately 15% 40% of Resistance associated an increased body mass index. The aim study was elucidate characteristics carbohydrate and lipid metabolism patients clomiphene-resistant PCOS o...

Clomiphene Citrate (Clomid, Serophene) was introduced into clinical medicine for the treatment of anovulation in the 1960’s. Its introduction represented a major breakthrough in the medical management for ovulation induction. Prior to Clomiphene, patients with PCOS who were anovulatory had few options besides weight loss and surgical wedge resection of the ovaries. While wedge resection was suc...

We report two sisters with profound insulin resistance associated with a novel heterozygous missense mutation in exon 19 (His1130Arg) of the insulin receptor gene. The eldest was seen after puberty at age 15 and she presented a severe form of polycystic ovary syndrome (PCOS) with biological hyperandrogenism (HA) mimicking a virilizing tumour. However, she has been able to ovulate under clomiphe...

Clomiphene Citrate (Clomid, Serophene) was introduced into clinical medicine for the treatment of anovulation in the 1960’s. Its introduction represented a major breakthrough in the medical management for ovulation induction. Prior to Clomiphene, patients with PCOS who were anovulatory had few options besides weight loss and surgical wedge resection of the ovaries. While wedge resection was suc...

objective: the aim of this study is to determine if simvastatin pretreatment would change clomiphene response in clomiphene citrate-resistant (cc-r)women with (pcos). materials and methods: this quasi experimental study included twenty five clomiphene resistant women with pcos. all patients received cyclic oral contraceptives pills (ocp) (30µg of ethinyl estradiol and 150µg of desogestrol) from...