نتایج جستجو برای: clonal expansion
تعداد نتایج: 162841 فیلتر نتایج به سال:
Skin papillomas arise as a result of clonal expansion of mutant cells. It has been proposed that the expansion of pretumoral cell clones is propelled not only by the increased proliferation capacity of mutant cells, but also by active cell selection. Previous studies in Drosophila describe a clonal selection process mediated by the Flower (Fwe) protein, whereby cells that express certain Fwe is...
Recently, we demonstrated that radiation (IR) instigates the occurrence of a NFκB-TNFα feedback cycle which sustains persistent NFκB activation in neuroblastoma (NB) cells and favors survival advantage and clonal expansion. Further, we reported that curcumin targets IR-induced survival signaling and NFκB dependent hTERT mediated clonal expansion in human NB cells. Herein, we investigated the ef...
Cancer arises through amultistage process, but it is not fully clear how this process influences the age-specific incidence curve. Studies of colorectal and pancreatic cancer using themultistage clonal expansion (MSCE)model have identified two phases of the incidence curves. One phase is linear, beginning about age of 60 years, suggesting that at least two rare rate-limitingmutations occur befo...
Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic and pro-thrombotic disorder associated with the clonal expansion of hematopoietic stem cells harboring somatic mutations in the PIG-A gene. Mutations in PIG-A result in a lack of surface expression of all glycosylphosphatidylinositol (GPI)-anchored proteins, including the complement inhibitors CD55 and CD59, which is responsible for the h...
Citation: Firrao G, Torelli E, Polano C, Ferrante P, Ferrini F, Martini M, Marcelletti S, Scortichini M and Ermacora P (2018) Genomic Structural Variations Affecting Virulence During Clonal Expansion of Pseudomonas syringae pv. actinidiae Biovar 3 in Europe. Front. Microbiol. 9:656. doi: 10.3389/fmicb.2018.00656 Genomic Structural Variations Affecting Virulence During Clonal Expansion of Pseudo...
The concept of 'field cancerization' describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones. We quantitatively analyze how the activation of oncogenic K-ras in individual Lgr5(+) stem cells...
Cancer arises through a multistage process, but it is not fully clear how this process influences the age-specific incidence curve. Studies of colorectal and pancreatic cancer using the multistage clonal expansion (MSCE) model have identified two phases of the incidence curves. One phase is linear, beginning about age of 60 years, suggesting that at least two rare rate-limiting mutations occur ...
conclusions the cd4+ and cd8+ tcr vβ gene families undergo clonal expansion in cshb patients, and cd8+ t cells play a major role in the pathogenesis of cshb. moreover, the conserved motifs and limited use of joining region genes observed in the cshb patients of this cohort indicated that similar antigenic epitopes are recognized. results the number of oligoclonal or monoclonal expansion tcr vβ ...
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