Purpose: Lamotrigine (LTG) is often used as adjunctive therapy in Lennox-Gastaut syndrome (LGS); however, it may worsen myoclonic and atypical absence seizures LGS patients. This study reviewed the overall efficacy safety of LTG children with LGS.Methods: retrospective included 38 patients (aged <18 years) who underwent between October 2020 March 2022 at Severance Children’s Hospital. The pr...

Hemifacial spasm (HFS) is characterized by paroxysmal bursts of involuntary clonic and tonic activity in muscles innervated by the facial nerve. Idiopathic HFS is hypothesized to be a result of microvascular compression of the facial nerve at its root exit zone in the brain stem. Symptomatic (secondary) HFS is usually caused by compression of the facial nerve’s root exit zone. Whether HFS can a...

Objective: Annona senegalenesis Pers is a sprawling shrub belonging to the family Annonaceae, and is mainly used in ethnomedicine. The use of decoction of A. senegalenesis is very prominent in the management of various conditions ranging from bacterial infection, worm infestation,  snake bites, pyrexia and febrile convulsion in folk medicine. Methods: The investigation on anti...

Objective: Annona senegalenesis Pers is a sprawling shrub belonging to the family Annonaceae, and is mainly used in ethnomedicine. The use of decoction of A. senegalenesis is very prominent in the management of various conditions ranging from bacterial infection, worm infestation,  snake bites, pyrexia and febrile convulsion in folk medicine. Methods: The investigation on anti...

A 7-month-old girl presented with a 4-week history of recurrent tonic spasms that occurred daily, predominantly upon awakening. She is able to roll over, however, is not sitting yet, and is not very attentive. Family history was unremarkable. Her head circumference was 40 cm, and she had no cutaneous signs. Neurologically, she had mild global hypotonia. No focal signs were noted. Notice: Author...

so persistent as in the tubercular form), suddenness of onset, then convulsive seizures and tonic spasms, much intolerance of being examined or handled, even when coma is beginning. The most striking clinical symptom is tonic spasm of the nuchal mv scles, with retraction of head, which cannot be replaced without great pain. Later, when effusion becomes established, and there is coma and Kernig'...

symptom spasmodic and tonic cramp in muscles, occurring suddenly and irregularly on attempting voluntary movement. In January, 1883, MM. Ballet and Marie published a case of this disease (.Archives de Ndurologie), naming it "muscular spasm at the commencement of voluntary movements." In March, 1883, Westphal brought two cases of the disease before the Society of Medicine of Berlin, and quoted s...

Introduction Epilepsy is a common neurological disorder that can cause anywhere from a brief cessation of responsiveness to severe muscle spasms with a loss of consciousness.1 This condition is usually controlled with antiepileptic drugs (AEDs). However, approximately 20% of patients with epilepsy are resistant to therapy with first-generation AEDs.2 Topiramate (Topamax®) is a second-generation...

The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure types, and to adopt more transparent names. Because current knowledge is insuffic...