post operative pain and its control remains one of the most important issues in the field of surgery and health care system. formalin test has been used as a method for assessing pain and analgesia in rats. systemic and spinally administered clonidine, an ?2-adrenergic agonist, is proved to enhance postoperative analgesia. it has also been shown that morphine-dependent rats experience more chro...

in this work, we have studied binding of clonidine drug (c9h9cl2n3) with zigzag single walled carbonnanotubes (swcnt) (5, 0) by theoretical methods of theory using gaussian 09 software package.binding energies, nmr parameters and homo- lumo gap energy were calculated. results frombinding energies indicate that it is possible thermodynamically to bind clonidine drug to swcnt.the calculated nmr p...

  Clonidine, an α2-adrenergic receptor agonist not only induces analgesia but also prolongs the effects of local anesthetic substances. In the present study the effects of clonidine on spontaneous and formalin-induced electrical activity from dorsal skin nerve were investigated. The results showed that clonidine (0.5 mM) decreased the formalin effect on electrical nerve activity whereas clonidi...

Background: Clonidine is used in critically ill patients for sedative and analgesic purposes. Objectives: 1) to review, systematically, the literature on prolonged intravenous (iv) clonidine for sedation in critically ill patients; 2) to evaluate the evidence from related fields of medicine on the use of clonidine for sedative or analgesic purposes, and; 3) to investigate prescribing practices ...

Clonidine hydrochloride has been used for pre-anesthetic medication to provide a pre-operative sedation in pediatric surgery. The purpose of this study is to determine the plasma clonidine concentration, which gives satisfactory sedation in pediatric surgery. Sixteen pediatric patients (age: 1-11 years, weight: 9-33 kg) received either 2 or 4 microg/kg of clonidine lollipop before entering the ...

Clonidine has sedative and analgesic properties. Randomized studies examining these properties in mechanically ventilated ICU patients are scarce. This study was designed to assess the impact of clonidine on sedative agent use in mechanically ventilated patients. In a prospective, randomized, double blind, placebo-controlled study in a general ICU of a university medical center in Tehran, Iran,...

Background. Dextromethorphan is a noncompetitive N-methyl D-aspartate receptor antagonist that is clinically feasible for relieving the opioid withdrawal symptoms. )is study compares the e*cacy of a combination therapy with dextromethorphan and clonidine to treatment with clonidine alone. Methods and Materials. In this double-blind randomized clinical trial, patients were selected from inpatien...

OBJECTIVE To compare withdrawal symptoms among pediatric intensive care patients receiving clonidine to those not receiving clonidine while being weaned from long-term dexmedetomidine. METHODS This retrospective analysis evaluated Withdrawal Assessment Tool-1 (WAT-1) scores and hemodynamic parameters in pediatric patients on dexmedetomidine for 5 days or longer between January 1, 2009, and De...

Clonidine is a medication used to treat high blood pressure, attention deficit hyperactivity sleep disorders, and hyperarousal caused by post-traumatic stress disorder,. . Jump up ^ "Clonidine and Guanfacine IR vs ER: Old Drugs With "New" of CNS noradrenergic activity in PTSD: the case for clonidine and prazosin.". Sep 17, 2013 . The FDA has only approved two SRIs for the treatment of PTSD: ser...

OBJECTIVE To examine the safety and tolerability of clonidine used alone or with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD). METHOD In a 16-week multicenter, double-blind trial, 122 children with ADHD were randomly assigned to clonidine (n = 31), methylphenidate (n = 29), clonidine and methylphenidate (n = 32), or placebo (n = 30). Doses were flexibly tit...