Cell-mediated immunity (CMI) to autologous breast can cer tissue was measured by means of skin window (SW) and leukocyte migration tests (LMT's). Simultaneous measurements were made of the in vitro (LMT) reactivity to Rlll-murine mammary tumor virus, virions and/or puri fied glycoprotein with a molecular weight of 55,000. Among clinically disease-free patients tested 6 to 12 months postoperativ...

Cell-mediated immunity (CMI) to autologous breast can cer tissue was measured by means of skin window (SW) and leukocyte migration tests (LMT's). Simultaneous measurements were made of the in vitro (LMT) reactivity to Rlll-murine mammary tumor virus, virions and/or puri fied glycoprotein with a molecular weight of 55,000. Among clinically disease-free patients tested 6 to 12 months postoperativ...

Women with recurrent vulvovaginal candidiasis often demonstrate a down-regulation of cell-mediated immunity (CMI) to Candida albicans detected by a lack of cutaneous delayed-type hypersensitivity (DTH) to Candida antigens. However, the role of systemic CMI as a host defense mechanism against recurrent vulvovaginal candidiasis is not well understood, in part because of the lack of a well-defined...

The Cornell Medical Index (CMI) is a well-known health questionnaire, of established value as an aid to clinical diagnosis and as a screening procedure (Brodman, Erdmann, and Wolff, 1956). A recent review of the use of the CMI as an epidemiological tool cites numerous studies which support its value for this purpose, particularly as an indicator of emotional ill-health (Abramson, in press). The...

The development of a preventive vaccine against human immunodeficiency virus (HIV-1) infection is the most efficient method to control the epidemic. The ultimate goal is to develop a vaccine able to induce specific neutralizing, non-neutralizing antibodies and cellular mediated immunity (CMI). Humoral and CMI responses can be directed to glycoproteins that are normally presented as a trimeric s...

Epstein-Barr virus (EBV) reactivation and cell-mediated immune (CMI) responses were followed in 16 Antarctic expeditioners during winter-over isolation at 2 Australian National Antarctic Research Expedition stations. Delayed-type hypersensitivity (DTH) skin testing was used as an indicator of the CMI response, that was evaluated 2 times before winter isolation and 3 times during isolation. At a...

A latent viral immune inflammatory response (LVIIR) model is presented which integrates factors that contribute to chronic multisymptom illness (CMI) in both the veteran and civilian populations. The LVIIR model for CMI results from an integration of clinical experience with a review of the literature in four distinct areas: (1) studies of idiopathic multisymptom illness in the veteran populati...

Major depression (MD) is one of the most common psychiatric disorders, severely affecting the quality of life of millions of people worldwide. Despite the availability of several classes of antidepressants, treatment efficacy is still very variable and many patients do not respond to the treatment. Clomipramine (CMI), a classical and widely used antidepressant, shows widespread interindividual ...

Our objective was to describe the CD4-mediated human immunodeficiency virus (HIV)-specific cell-mediated immunity (CMI) and its virologic and immunologic correlates in children with chronic HIV infection on highly active antiretroviral therapy (HAART). Twelve HIV-infected children on stable antiretroviral therapy with a median level of CD4+ lymphocytes (CD4%) of 25.5% and a median viral load (V...

BACKGROUND We studied whether severely immunocompromised, human immunodeficiency virus (HIV)-infected children who were beginning highly active antiretroviral therapy (HAART) or changing HAART regimens could spontaneously respond to a recall antigen (tetanus toxoid [TT] vaccine) or respond to a recall antigen and neoantigen (hepatitis A virus [HAV] vaccine) after 3 vaccinations. METHODS A tot...