OBJECTIVE Advanced glycation end products (AGEs) are a risk factor for diabetic complications. We have developed an assay method for N-(carboxymethyl)valine (CMV) of the hemoglobin (CMV-Hb), which is an AGE generated from HbA1c. Herein we describe the clinical utility of CMV-Hb measurement for the diagnosis of diabetic nephropathy RESEARCH DESIGN AND METHODS BALB/c mice were immunized with ca...

Cytomegalovirus (CMV) infection in immunocompetent adults is usually asymptomatic, but results lifelong latency. Infection occurring congenitally or immunodeficiency can lead to cognitive impairment. We aimed investigate the associations between CMV exposure and intelligence quotient (IQ) patients with schizophrenia spectrum disorders (SZS), bipolar (BDS) healthy controls (HC). immunoglobulin G...

Aim. Screening of vegetable crops for mixed viral infections caused by 8 viruses, and evaluation relative share different combinations pathogens using serological methods plant virus diagnostics. Methods. Double-antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) was performed detection antigens. Results. For this study, the samples from plants with virus-like symptoms were collecte...

The presence of immunoglobulin G receptors in human fibroblasts infected with human cytomegalovirus (CMV) resulted in a nonspecific cytoplasmic reaction in the indirect fluorescent-antibody test. Both CMV antibody-positive and antibody-negative sera from human or other animal species produced the cytoplasmic reaction. The substitution of a simian CMV strain for the human virus successfully elim...

OBJECTIVES Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 years on ART. DESIGN We describe longitudinal analyses of plasma from 13 HIV ...

Background: Human Cytomegalovirus (CMV) is one of the most significant pathogens infecting immunosuppressed individuals. CMV is known to be a significant cause of morbidity and mortality following blood transfusion in immunocompromised individuals. The immunosuppressed population for whom CMV free blood products are requested is increasing due to advances in medical care. The most effective way...

with Anti-MAG/SGPG Antibody–Associated Neuropathy Sachiko Irie, MD, PhD,* Naomi Kanazawa, BS,† Mieko Ogino, MD, PhD,* Toyokazu Saito, MD, PhD,* and Tadao Funato, PhD‡ In a recent study by Yuki and colleagues, cytomegalovirus (CMV) DNA was detected in sera from 23 of 26 patients (88%) with IgM anti-myelin–associated glycoprotein (antiMAG)/sulfated glucuronyl paragloboside (SGPG) antibody– associ...

conclusions this is the first report of expression of cmv cp gene in iran, which is important for the preparation of anti-cmv antibody and paving the way for the use of the virus coat protein as a nanomaterial. results the identity of the expressed protein was confirmed by immunoassays such as western blot, dot-immunobinding assay (diba) and enzyme-linked immunosorbent assay (elisa) by the use ...

BACKGROUND Umbilical cord blood (UCB) is believed to be a highly valuable source of hematopoietic stem cells for transplantation. Objective: To investigate the prevalence of active and latent human cytomegalovirus (CMV) infection in UCB donors in Iranian population. METHODS A total of 825 UCB samples was collected under standard procedures and analyzed for the presence of CMV DNAs in buffy co...

We evaluated a new membrane dot immunobinding assay (CMV-CUBE; Difco Laboratories) for the detection of cytomegalovirus (CMV) antibody in marrow transplant patients and donors. The CMV-CUBE assay was compared with a commercially available enzyme immunoassay (EIA; CMV STAT) and a latex agglutination (LA; CMVScan) test. Serum samples were collected from 311 transplant patients and donors prior to...