Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and still remains incurable. Although immunotherapeutic vaccination against GBM has demonstrated immune-stimulating activity with some promising survival benefits, tumor relapse is common, highlighting the need for additional and/or combinatorial approaches. Recently, antibodies targeting immune checkpoints were demo...

CNS: central nervous system IHC: immunohistochemistry MMR: mismatch repair MTS: Muir-Torre syndrome M uir-Torre syndrome (MTS) is an autosomal-dominant variant of Lynch hereditary cancer syndrome. MTS is defined by sebaceous neoplasms occurring in association with 1 or more internal malignancies. The sebaceous neoplasms that characterize MTS are rare among the general population and include seb...

• STI1 is a co-chaperone involved in the correct client proteins' folding. Extracellular crucial for CNS maintenance and homeostasis. expression associated with tumor progression impaired survival of patients. can be biomarker therapeutic target several malignancies. Stress inducible protein 1 (STI1) acting Hsp70 Hsp90 proteins’ folding therefore cellular Besides being expressed cytosol, also f...

To highlight the importance of a broad differential diagnosis, including malignancy, in patients with central nervous system vasculitis (CNSV) presenting as multiple, recurrent cryptogenic strokes.

BACKGROUND Cryptococcal infection has become a public health challenge globally. However, information about cryptococcal infection in patients with hematological diseases remains relatively rare. METHODS HIV-uninfected cryptococcosis cases with hematological diseases admitted to Huashan Hospital from January 2001 to December 2014 were reviewed. RESULTS In total, 33 cryptococcosis patients w...