Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacularization (CNV), could result in rapid and severe loss of central vision. The critical role of vascular endothelial growth factor A (VEGF-A) in CNV development has been established and VEGF-A neutra...

PURPOSE Inflammation and immune cells regulate choroidal neovascularization (CNV) and could become therapeutic targets in age-related macular degeneration (AMD). Lymphangiogenesis is a key component of various inflammatory diseases. Whether lymphangiogenesis and lymph node-mediated immunity are involved in the pathogenesis of AMD is not understood. METHODS To investigate lymphangiogenesis in ...

Noroviruses are associated with intestinal disease in humans, cows, pigs, mice, and, more recently, dogs. In 2007, the first canine norovirus (CNV) was identified and characterized in Italy. Subsequent studies have identified CNV in stools of dogs from Portugal, Greece, and the United States. To investigate the prevalence of CNV in the UK dog population, 228 canine stool samples were screened f...

Copy number variation (CNV) or single nucleotide phlyorphism (SNP) is useful genetic resource to aid in understanding complex phenotypes or deseases susceptibility. Although thousands of CNVs and SNPs are currently avaliable in the public databases, they are somewhat difficult to use for analyses without visualization tools. We developed a web-based tool called the VCS (visualization of CNV or ...

BACKGROUND Glyphosate has been used for weed control in South China various situations four decades, and most Eleusine indica populations are suspected to have evolved resistance glyphosate. This research investigated underling target-site glyphosate mechanisms six field-collected, putative glyphosate-resistant (R) E. populations. RESULTS The R were confirmed be low (1.8 2.6-fold) moderately (5...

AIMS To investigate the relationship between idiopathic choroidal neovascularisation (CNV) and choroidal watershed zones (CWZs) using indocyanine green angiography (ICGA). DESIGN Multicentre, retrospective, interventional case series. METHODS The medical records and ICGA findings of 44 patients (44 eyes) diagnosed with idiopathic CNV were reviewed. CWZs, defined as hypofluorescence that dis...

Since the first description of CNV (contingent negative variation) by Walter in 1964, many reports on this phenomenon have appeared, mainly in the psychiatric field. In this report, CNV was recorded in neurosurgical patients under three experimental conditions which differed as to the level of difficulty in concentrating on the conditioned tasks. Under the 1st condition, CNV was recorded withou...

PURPOSE Dendritic cells (DCs) are innate immune cells that have recently been shown to support angiogenesis in tumors, endometriosis, and lymph nodes. A major cause of legal blindness is wet age-related macular degeneration (wet ARMD), wherein abnormal blood vessels grow under the retina, an abnormality also referred to as choroidal neovascularization (CNV). The purpose of the present study was...

Objective: To evaluate the effect of intravitreal injection with anti-CD40 ligand antibody (anti-CD40L) on choroidal neovascularization (CNV) in a laser-induced CNV mouse model. Methods: Anti-CD40L (0.5 mg/ml, 1 μl), anti-VEGF (0.5 mg/ml, 1 μl) or PBS (1×, 1 μl) was injected into the vitreous body of C57BL/6J mice at day 3 after laser photocoagulation. Changes in CNV lesions were evaluated by i...

PURPOSE The exudative, or the wet form of age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV). A subretinal Matrigel (BD Biosciences, Bedford MA) model of CNV is described here, along with the effects of vascular endothelial growth factor (VEGF) neutralization on the development of CNV and associated inflammation and fibrosis. METHODS CNV was induced ...