نتایج جستجو برای: coagulation factor ix

تعداد نتایج: 893342  

Journal: :Blood 1972
C H Brown L K Kvols T H Hsu J Levin

Factor IX deficiency was associated with a hemorrhagic disorder in a woman who previously had experienced postpartum hypotension resulting in Sheehan’s syndrome. There was no family history of Christmas disease, and other known causes of factor IX deficiency were excluded. Plasma levels of factor IX were partially corrected by therapy with thyroid hormones and completely restored to normal by t...

Journal: :iranian journal of medical sciences 0
a. zahedmehr department of biotechnology, pas-teur institute of iran, tehran, iran s. delmaghani department of biotechnology, pas-teur institute of iran, tehran, iran r. sharifian hemophilia centre, imam khomeini hospital, tehran university of medical sciences, tehran, iran m. lak hemophilia centre, imam khomeini hospital, tehran university of medical sciences, tehran, iran s. zeinali department of biotechnology, pas-teur institute of iran, tehran, iran

background: hemophilia b is an x-linked recessive coagulation disorder caused by factor ix deficiency.  analysis of factor ix gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of hemophilia b where the identification of gene mutation is not easily possible.   objective: to study the frequency of three factor ix-linked restriction fragment length pol...

Journal: :Japanese Journal of Thrombosis and Hemostasis 2012

Journal: :international journal of pediatrics 0
hassan mansouritorghabeh allergy research center, ghaem hospital, mashhad university of medical sciences, faculty of medicine, mashhad, iran. alireza modarresi professor of pediatric hematology, department of pediatrics, imam reza hospital, ghaem hospital, mashhad university of medical sciences, faculty of medicine, mashhad, iran.

background bone marrow transplantation (bmt)is nowadays used in various hematological disorders including leukemias. hemophilia a & b are sex linked bleeding disorders in which there are various genetic abnormalities in factor viii & ix genes. among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor viii & ix c...

2008
Yang Buyue John P. Sheehan

The role of the factor IXa heparin-binding exosite in coagulation was assessed with mutations that enhance (R170A) or reduce (R233A) stability of the proteasefactor VIIIa A2 domain interaction. After tissue factor (TF) addition to reconstituted factor IX-deficient plasma, factor IX R170A supported a 2-fold increase in velocity index (slope) and peak thrombin concentration, whereas factor IX R23...

Journal: :Blood 2008
Yang Buyue Herbert C Whinna John P Sheehan

The role of the factor IXa heparin-binding exosite in coagulation was assessed with mutations that enhance (R170A) or reduce (R233A) stability of the protease-factor VIIIa A2 domain interaction. After tissue factor (TF) addition to reconstituted factor IX-deficient plasma, factor IX R170A supported a 2-fold increase in velocity index (slope) and peak thrombin concentration, whereas factor IX R2...

Alireza Modarresi Hassan Mansouritorghabeh

Background Bone marrow transplantation (BMT)is nowadays used in various hematological disorders including leukemias. Hemophilia A & B are sex linked bleeding disorders in which there are various genetic abnormalities in factor VIII & IX genes. Among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor VIII & IX ...

Journal: :Blood 1990
P M Mannucci K A Bauer A Gringeri S Barzegar B Bottasso L Simoni R D Rosenberg

Prothrombin complex concentrates (PCC), licensed for the treatment of hemophilia B, are known to carry a significant risk of thromboembolic complications. Although the reasons for thrombogenicity are not completely understood, several manufacturers have developed purified factor IX concentrates that contain negligible amounts of the other vitamin K-dependent factors. To evaluate whether or not ...

2005
Catherine Driscoll Eric Bouhassira Louis M. Aledort

Hemophilia B is an X-Iinked recessive bleeding disorder resulting from a deficiency of the coagulation factor IX (FIX) protein activity. a vitamin K-dependent serine protease active in both the intrinsic and extrinsic coagulation systems. DNA analyses of the factor IX gene in two unrelated patients with severe hemophilia B. with a IX coagulant activity <1 % and undetectable FIX antigen. detecte...

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