Despite the large number of the outstanding researches, pathogenesis of osteonecrosis remains unknown. During the last decades the hypothesis that increased intravascular coagulation may be the pathogenetic mechanism which leads to osteonecrosis is gaining constantly support. Both primary factors of hyper-coagulability, such as resistance to activated protein C, protein C and protein S deficien...

Coronavirus disease (COVID-19) can induce coagulopathy at the base of sepsis-induced coagulopathy (SIC), which is an important cause of death in these patients. Cytokine storm causes imbalance in coagulation and fibrinolytic system. A combination of hypercoagulability state, decrease or inhibition of fibrinolysis and endotheliopathy causes thromboembolic events. Underlying diseases such as diab...

Background Infertility is the inability to conceive children after one year of unprotected intercourse. The estimated prevalence of infertility in Canada is 11.5-15.7%. Fertility problems affect approximately one in seven couples in the United Kingdom (UK). Infertility occurs in conditions in which the pregnancies end with recurrent miscarriages (ASR) or birth of a child with multiple congenita...

Soy protein favorably alters serum lipids and lipoproteins in hypercholesterolemic individuals, thereby reducing cardiovascular disease risk. The primary purpose was to determine the effect of soy protein (40 g/d) on circulating lipids and lipoproteins or coagulation and fibrinolytic factors in normocholesterolemic and mildly hypercholesterolemic perimenopausal women. We also determined the con...

INTRODUCTION: Maintaining optimal coagulation is vital for successful microvascular flap transfer. Hypercoagulate states are risk factors for pedicle thrombosis and flap loss.1 Therefore, identifying patients who are at risk for such events is paramount. The viscoelastic Thromboelastography (TEG) is a modern method to assess a patient’s coagulation status and in the past, it has predominantly b...

INTRODUCTION: Maintaining optimal coagulation is vital for successful microvascular flap transfer. Hypercoagulate states are risk factors for pedicle thrombosis and flap loss.1 Therefore, identifying patients who are at risk for such events is paramount. The viscoelastic Thromboelastography (TEG) is a modern method to assess a patient’s coagulation status and in the past, it has predominantly b...

multiple sclerosis (ms) is a neuroinflammatory autoimmune disease which mediated by various molecular and cellular immune components however recent reports have shown that coagulation factors that traditionally separate from the immune system might also be involved in ms development and progression.studies on experimental autoimmune encephalomyelitis (eae) and human ms patients reports alterati...

In 1976, Hampton and Mitchell concluded their textbook chapter on thrombosis thus: The study of the epidemiology of arterial and venous disease has provided some indicators of where we might look for the causes of thrombosis, but the mechanisms involved are far from clear.... It is, however, possible that empirical advances may occur in the identification of anti-thrombotic drugs despite our ig...