conclusions the results of the first human pharmacokinetic studies of aminorex were first characterized in 2013. the results suggest that while humans could produce aminorex from levamisole, they probably do not convert very much. even though cases of pah have been reported in cocaine users, the latest pharmacokinetic studies suggest that very little aminorex is actually produced from the inges...

Cocaine-associated coronary artery disease and ST-segment elevation myocardial infarction (STEMI) have been well described in the literature. However, very few cases of cocaine-induced multivessel reported. We report a rare case cocaine-associated triple vessel 41-year-old male patient. The patient underwent urgent catheterization that revealed occlusion his proximal left anterior descending (L...

abstract most pheochromocytomas are not suspected clinically while a high percentage of them are curable with surgery. we present the case of an adult cocaine-addicted male patient with an underlying pheochromocytoma and repeated myocardial infarctions. computed tomography showed a left round adrenal mass, also high 24-hour urine levels of catecholamines and metanephrines were detected from uri...

introduction we present a case report of a healthy man who ingested a large number of well-manufactured cocaine packages to smuggle them across international borders. case presentation a 36-year-old man ingested cocaine packages worth approximately us $900,000 to transport it from dubai to madrid. he was arrested by police at istanbul ataturk airport for suspected body packing of drugs. on arri...

OBJECTIVE To review and discuss the differences and similarities between the use of crack cocaine and cocaine hydrochloride; and to determine how these findings might affect policies on the imprisonment and treatment of cocaine users. DATA SOURCES English-language publications were identified through a computerized search (using MEDLINE) between 1976 and 1996 using the search terms "smoked co...

The orexin/hypocretin system is involved in multiple cocaine addiction processes that involve drug-associated environmental cues, including cue-induced reinstatement of extinguished cocaine seeking and expression of conditioned place preference. However, the orexin system does not play a role in several behaviors that are less cue-dependent, such as cocaine-primed reinstatement of extinguished ...

The anti-alcoholism medication, disulfiram (Antabuse), decreases cocaine use in humans regardless of concurrent alcohol consumption and facilitates cocaine sensitization in rats, but the functional targets are unknown. Disulfiram inhibits dopamine β-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons. The goal of this study was to test the e...

Crack-cocaine offers a higher risk of abuse than intranasal and intravenous use cocaine. Yet, current treatments remain disappointing our understanding the mechanism crack-cocaine neurotoxicity is still incomplete. Magnetic resonance images studies on brain changes addicts show divergent data. The present study investigated gray matter (GM) abnormalities in dependents (n = 18) compared to healt...

The present study compared interactions among dopamine D1-like agonists and partial agonists with cocaine on the locomotor stimulant effects of cocaine, as well as the discriminative-stimulus effects of cocaine, and effects of cocaine on rates of responding. Cocaine alone produced a dose-related stimulation of locomotor activity in Swiss-Webster mice and a dose-related increase in the proportio...

Two unique metabolites of cocaine, cocaethylene and norcocaine, were identified by GC/MS in the hair of cocaine users. Their presence cannot be explained by environmental contamination; thus, their presence together with cocaine provides convincing evidence that cocaine is excreted in hair after active cocaine administration. The amount of cocaine in hair predominated over all metabolites gener...