The GxxxG motif is frequently found at the dimerization interface of a transmembrane structural motif called GASright, which is characterized by a short interhelical distance and a right-handed crossing angle between the helices. In GASright dimers, such as glycophorin A (GpA), BNIP3, and members of the ErbB family, the backbones of the helices are in contact, and they invariably display networ...

3',5'-cyclic adenosine monophosphate (cAMP) dependent protein kinase or protein kinase A (PKA) has served as a prototype for the large family of protein kinases that are crucially important for signal transduction in eukaryotic cells. The PKA catalytic subunits Cα and Cβ, encoded by the two genes PRKACA and PRKACB, respectively, are among the best understood and characterized human kinases. Her...

We consider the following inverse problems for the class Cα of unilevel block α-circulants C = [Cs−αr ] k−1 r,s=0, where k > 1, C0, C1, . . . , Ck−1 ∈ Cd1×d2 , α ∈ {1, 2, . . . , k − 1}, gcd(α, k) = 1, and ‖ · ‖ is the Frobenius norm. Problem 1 Find necessary and sufficient conditions on Z ∈ Ckd2×h and W ∈ C1 for the existence of C ∈ Cα such that CZ = W , and find all such C if the conditions a...

We prove several weighted inequalities involving the Hilbert transform of a function f (x) and its derivative. One of those inequalities, − ∫ fx(x)[Hf (x)−Hf (0)] |x|α dx Cα ∫ (f (x)− f (0))2 |x|1+α dx, is used to show finite time blow-up for a transport equation with nonlocal velocity. © 2006 Elsevier Masson SAS. All rights reserved. Résumé Dans cet article nous présentons la démonstration de ...

Proteins are often characterized in terms of their primary, secondary, tertiary, and quaternary structure. Algorithms such as define secondary structure of proteins (DSSP) can automatically assign protein secondary structure based on the backbone hydrogen-bonding pattern. However, the assignment of secondary structure elements (SSEs) becomes a challenge when only the Cα coordinates are availabl...

Originally, as described in [12], the SWα-equations discovered by Seiberg and Witten are 1-order partial differential equations, which solutions (A,φ), with φ 6= 0, are known as SWα-monopoles. It is known that the solutions of these 1-order SWα-equations correspond to the minimum of the functional SWα : Cα → R. However, it is not true that the minimum of SWα : Cα → R is always attained by this ...

there exists an association between pi3k pathway licentious activity and the considerable feature of high metastatic potential of the genitourinary cancer cells. although du 145 and 5637 have functional phosphatase and tensin homolog (pten) tumor suppressor gene, which antagonizes pi3k function, pc-3 is null for pten gene. in pursuit to explain why pten bearing cell lines display high metastati...

Carbon hydrogen bonds between Cα-H donors and carbonyl acceptors are frequently observed between transmembrane helices (Cα-H···O=C). Networks of these interactions occur often at helix-helix interfaces mediated by GxxxG and similar patterns. Cα-H hydrogen bonds have been hypothesized to be important in membrane protein folding and association, but evidence that they are major determinants of he...

At least since Gabriel (1969), a broad class of multiple comparison procedures, socalled simultaneous test procedures (STPs), is established in the statistical literature. Elements of an STP are a testing family (H, T ), consisting of a set of null hypotheses and corresponding test statistics, and a common critical constant cα. The threshold cα with which each of the test statistics has to be c...

The issue of Cα-degree reduction of triangular Bézier surfaces is exposed. It is anticipated that both triangular Bézier surfaces are Cα-continuous at the vertices. The Euclidean norm as well as the L2−norm is used. The final solutions are given in terms of the matrix of degree raising, the Gram matrix, and the Bézier points. Moreover, it is shown that the solutions using both norms are equival...