A well defined cohort of coeliac patients was studied prospectively to assess the prevalence of coexisting thyroid disease and positive thyroid autoantibodies. Comparison with epidemiological data on the prevalence of coeliac disease in a neighbouring area suggested that few adult coeliac patients had been missed. Overall, 14% of the coeliac patients had thyroid disease: 10.3% were hypothyroid ...

over the last five decades the association between coeliac disease and other autoimmune disorders such as autoimmune thyroid disease or diabetes mellitus type 1 has been well established through many studies and to this day is subject to on-going clinical and scientific investigation worldwide. while no link has been established between coeliac disease and type 2 diabetes mellitus, coeliac dise...

BACKGROUND The lactulose/mannitol (L/M) intestinal permeability test is a simple, non-invasive screening test for coeliac disease. The reliability of the L/M test has so far only been tested in selected groups of patients with coeliac disease. AIM To evaluate the reliability of the L/M test in a group of patients with coeliac disease who had been diagnosed during mass serological screening of...

The functional integrity of the small bowel is impaired in coeliac disease. Intestinal permeability, as measured by the sugar absorption test probably reflects this phenomenon. In the sugar absorption test a solution of lactulose and mannitol was given to the fasting patient and the lactulose/mannitol ratio measured in urine collected over a period of five hours. The sugar absorption test was p...

BACKGROUND Patients diagnosed with irritable bowel syndrome may have coeliac disease. AIM To evaluate the cost-effectiveness of coeliac disease testing in suspected irritable bowel syndrome. METHODS We used decision analysis to estimate the number of coeliac disease cases detected, quality-adjusted life-years gained, and costs resulting from testing suspected irritable bowel syndrome patien...

The prevalence of coeliac disease among patients with autoimmune hypothyroidism has not been studied before in Jordan and other Arab countries. A cross-sectional record-based review was made of all adult autoimmune hypothyroidism patients who attended a referral centre in Jordan, during an 8-month period. Coeliac disease in these patients was diagnosed by the attending physician based on positi...

BACKGROUND New evidence emerged on early feeding practices and the risk of coeliac disease. AIM To systematically update evidence on these practices to find out whether there is a need to revise current recommendations. METHODS MEDLINE, EMBASE and the Cochrane Library were searched from July 2012 (end of last search) to February 2015 for studies of any design that assessed the effect of glu...

BACKGROUND There exists a wide variation in the reported incidence of coeliac disease in recent decades. We aimed to evaluate the incidence rate of coeliac diagnoses performed in an Italian region, Campania, between 2011 and 2013 and its variation therein. METHODS All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identifie...

BACKGROUND Up to 50% of women with untreated coeliac disease experience miscarriage or an unfavourable outcome of pregnancy. In most cases, after 6-12 months of a gluten free diet, no excess of unfavourable outcome of pregnancy is observed. The prevalence of undiagnosed coeliac disease among pregnant women is not known. AIM To determine the prevalence of untreated coeliac disease among women ...

Carswell, F., and Ferguson, A. (1972). Archives of Disease in Childhood, 47, 594. Food antibodies in serum-a screening test for coeliac disease. Food antibody tests were performed on the sera of 52 children undergoing investigation for suspected coeliac disease. 30 of these were subsequently shown to have coeliac disease. The food antibody tests were at least as effective a screening test for c...