Class cohesion is considered as one of most important object-oriented software attributes. Cohesion refers to the degree of relatedness between members in a class. High cohesion is a desirable property of classes. Several metrics have been proposed in literature in order to measure class cohesion in object-oriented systems. They capture class cohesion in terms of connections between members wit...

Telomeres use distinct mechanisms (not used by arms or centromeres) to mediate cohesion between sister chromatids. However, the motivation for a specialized mechanism at telomeres is not well understood. Here we show, using fluorescence in situ hybridization and live-cell imaging, that persistent sister chromatid cohesion at telomeres triggers a prolonged anaphase in normal human cells and canc...

Accurate chromosome partitioning during cell division requires that cohesion hold sister chromatids together until kinetochores correctly attach to spindle microtubules. In 1932, Darlington noted that sister-chromatid cohesion distal to the site of exchange also could play a vital role in maintaining the association of chiasmate homologs during meiosis. Cohesion linking a recombinant chromatid ...

Cohesion was rst developed to predict properties of implementations created from a given design. Unfortunately, cohesion, as originally de ned, could not be objectively assessed, while more recently developed objective cohesion measures depend on code-level information. We show that association-based and slicebased approaches can be used to measure cohesion using only design-level information. ...

Context: Several metrics have been proposed to measure the extent to which class members are related. Connectivity-based class cohesion metrics measure the degree of connectivity among the class members. Objective: We propose a new class cohesion metric that has higher discriminative power than any of the existing cohesion metrics. In addition, we empirically compare the connectivity and non-co...

Sister chromatid cohesion mediated by the cohesin complex is essential for chromosome segregation in mitosis and meiosis [1]. Rec8-containing cohesin, bound to Smc3/Smc1α or Smc3/Smc1β, maintains bivalent cohesion in mammalian meiosis [2-6]. In females, meiotic DNA replication and recombination occur in fetal oocytes. After birth, oocytes arrest at the prolonged dictyate stage until recruited t...

Cohesion has been a topic of interest since structured design [20, 23] in the 1970’s. Today, there are numerous researchers continuing this work into object-oriented designs [1, 3, 5, 7, 9, 10, 12, 13, 16, 18, 19, 22]. Most of the current research has focused on the interaction of methods within a class, the inter-method cohesion. In this paper we consider both the inter-method cohesion and the...

Cohesin complex mediates cohesion between sister chromatids, which promotes high-fidelity chromosome segregation. Eco1p acetylates the cohesin subunit Smc3p during S phase to establish cohesion. The current model posits that this Eco1p-mediated acetylation promotes establishment by abrogating the ability of Wpl1p to destabilize cohesin binding to chromosomes. Here we present data from budding y...

Cohesins are required both for the tethering together of sister chromatids (termed cohesion) and subsequent condensation into discrete structures-processes fundamental for faithful chromosome segregation into daughter cells. Differentiating between cohesin roles in cohesion and condensation would provide an important advance in studying chromatin metabolism. Pds5 is a cohesin-associated factor ...